part1-02786826.2020.1792824.pdf (2.39 MB)
A cross-industry assessment of the flow rate-time profiles of test equipment typically used for dry-powder inhaler (DPI) testing: Part 1 – compendial apparatuses
journal contribution
posted on 2020-07-16, 13:17 authored by R Greguletz, PU Andersson, A Cooper, F Chambers, MA Copley, G Daniels, M Hamilton, M Hammond, H Mohammed, DL Roberts, C Shelton, Hendrik Versteeg, JP MitchellWe report a cross-industry study characterizing flow rate-time profiles of equipment used for testing dry-powder inhalers
(DPIs). Nine organizations used the same thermal mass flow sensor to record flow rate-time profiles at the inlet of
individual participant compendial DPI test systems including either sample collection tubes (SCT), the Andersen 8-stage
non-viable impactor (ACI) or the Next Generation Impactor (NGI™) with and without pre-separator (PS). The plan
included some tests with a surrogate DPI consisting of one of three inlet orifices chosen to generate a 4-kPa pressure drop
at each of the target final flow rates of 30, 60, and 90 l.min−1, simulating the pressure drop typical of high-, medium-, and
low-resistance DPIs. When a particular surrogate DPI was present at the inlet, rise times to 90% of these target flow rates
(t90) were shortest at the highest target flow rate, and decreased linearly with decreasing apparatus internal volume,
following the order: NGI-PS>NGI>ACI-PS>ACI>SCT. A flow acceleration parameter was also evaluated, expressed as
the slope between the rise times when the flow rate attained 20% and 80% of each final steady flow rate (slopet20/80).
Flow acceleration was smallest at the lowest target flow rate, decreasing exponentially with increasing internal volume.
Measurements were also made without the surrogate DPI, providing a reference condition with no resistance at the inlet
to the apparatus. These flow rate-rise time profiles will be useful for those involved in evaluating equipment for
characterizing DPIs and in understanding the behavior of these inhalers in development or commercial production.
History
School
- Mechanical, Electrical and Manufacturing Engineering
Published in
Aerosol Science and TechnologyVolume
54Issue
12Pages
1424 - 1447Publisher
Taylor and FrancisVersion
- AM (Accepted Manuscript)
Rights holder
© American Association for Aerosol ResearchPublisher statement
This is an Accepted Manuscript of an article published by Taylor & Francis in Aerosol Science and Technology on 14 August 2020, available online: https://doi.org/10.1080/02786826.2020.1792824.Acceptance date
2020-06-18Publication date
2020-08-14Copyright date
2020ISSN
0278-6826eISSN
1521-7388Publisher version
Language
- en
Depositor
Mr Hendrik Versteeg . Deposit date: 14 July 2020Usage metrics
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