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A framework for model reliability and estimability analysis of crystallization processes with multi-impurity multi-dimensional population balance models

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journal contribution
posted on 10.09.2018 by Dimitris Fysikopoulos, Brahim Benyahia, Akos Borsos, Zoltan Nagy, Chris Rielly
The development of reliable mathematical models for crystallization processes may be very challenging due the complexity of the underlying phenomena, the inherent Population Balance Models (PBMs) and the large number of parameters that need to be identified from experimental data. Due to the poor information content of the experiments, the structure of the model itself and correlation between model parameters, the mathematical model may contain more parameters than can be accurately and reliably identified from the available experimental data. A novel framework for parameter estimability for guaranteed optimal model reliability is proposed then validated by a complex crystallization process. The latter is described by a differential algebraic system which involves a multi-dimensional population balance model that accounts for the combined effects of different crystal growth modifiers/impurities on the crystal size and shape distribution of needle-like crystals. Two estimability methods were combined: the first is based on a sequential orthogonalization of the local sensitivity matrix and the second is Sobol, a variance-based global sensitivities technic. The framework provides a systematic way to assess the quality of two nominal sets of parameters: one obtained from prior knowledge and the second obtained by simultaneous identification using global optimization. A cut-off value was identified from an incremental least square optimization procedure for both estimability methods, providing the required optimal subset of model parameters. The implemented methodology showed that, although noisy aspect ratio data were used, the 8 most influential and least correlated parameters could be reliably identified out of twenty-three, leading to a crystallization model with enhanced prediction capability.

Funding

The authors would like to thank EPSRC and the Doctoral Training Centre in Continuous Manufacturing and Crystallization (Grant ref: EP/K503289/1) for funding D.F. and the European Research Council (Grant ref: 200106-CrySys) for funding A.B.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Published in

Computers & Chemical Engineering

Citation

FYSIKOPOULOS, D. ... et al, 2018. A framework for model reliability and estimability analysis of crystallization processes with multi-impurity multi-dimensional population balance models. Computers & Chemical Engineering, 122, pp.275-292

Publisher

Elsevier (© The authors)

Version

VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution 4.0 International (CC BY 4.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/ by/4.0/

Acceptance date

03/09/2018

Publication date

2018

Notes

This is an Open Access Article. It is published by Elsevier under the Creative Commons Attribution 4.0 International Licence (CC BY). Full details of this licence are available at: https://creativecommons.org/licenses/by/4.0/.

ISSN

0098-1354

Language

en

Licence

Exports