Malkov_e-Reduction N-oxides-3d-finalYF.pdf (561.99 kB)
A mild method for electrochemical reduction of Heterocyclic N-Oxides
journal contribution
posted on 2020-05-20, 13:09 authored by Yasuaki Fukazawa, Aleksandr E Rubtsov, Andrei MalkovAndrei MalkovDeoxygenation of heteroaromatic N-oxides is commonly accomplished using chemical or enzymatic methods. In this work, we report on an expedient protocol for electrochemical reduction of pyridine N-oxide derivatives under mild conditions. A diverse range of mono- and bis-N-oxides were converted into the corresponding nitrogen bases in good yields. Importantly, the method is highly selective towards N-oxides and tolerates challenging halo and nitro substituents in the heteroaromatic ring.
Funding
Russian Science Foundation for grant 18- 73-10156
History
School
- Science
Department
- Chemistry
Published in
European Journal of Organic ChemistryVolume
2020Issue
22Pages
3317 - 3319Citation
Fukazawa, Y., Rubtsov, A.E. and Malkov, A.V., (2020), A mild method for electrochemical reduction of Heterocyclic N-Oxides. European Journal of Organic Chemistry, 2020 (22), pp.3317-3319.Publisher
WileyVersion
- AM (Accepted Manuscript)
Rights holder
© WileyPublisher statement
This is the peer reviewed version of the following article: Fukazawa, Y., Rubtsov, A.E. and Malkov, A.V., (2020), A mild method for electrochemical reduction of Heterocyclic N-Oxides. European Journal of Organic Chemistry, 2020 (22), pp.3317-3319, which has been published in final form at https://doi.org/10.1002/ejoc.202000377. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived VersionsAcceptance date
2020-04-09Publication date
2020-05-08Copyright date
2020ISSN
1434-193XeISSN
1099-0690Publisher version
Language
- en