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A mild method for electrochemical reduction of Heterocyclic N-Oxides

journal contribution
posted on 20.05.2020 by Yasuaki Fukazawa, Aleksandr E Rubtsov, Andrei Malkov
Deoxygenation of heteroaromatic N-oxides is commonly accomplished using chemical or enzymatic methods. In this work, we report on an expedient protocol for electrochemical reduction of pyridine N-oxide derivatives under mild conditions. A diverse range of mono- and bis-N-oxides were converted into the corresponding nitrogen bases in good yields. Importantly, the method is highly selective towards N-oxides and tolerates challenging halo and nitro substituents in the heteroaromatic ring.

Funding

Russian Science Foundation for grant 18- 73-10156

History

School

  • Science

Department

  • Chemistry

Published in

European Journal of Organic Chemistry

Volume

2020

Issue

22

Pages

3317 - 3319

Citation

Fukazawa, Y., Rubtsov, A.E. and Malkov, A.V., (2020), A mild method for electrochemical reduction of Heterocyclic N-Oxides. European Journal of Organic Chemistry, 2020 (22), pp.3317-3319.

Publisher

Wiley

Version

AM (Accepted Manuscript)

Rights holder

© Wiley

Publisher statement

This is the peer reviewed version of the following article: Fukazawa, Y., Rubtsov, A.E. and Malkov, A.V., (2020), A mild method for electrochemical reduction of Heterocyclic N-Oxides. European Journal of Organic Chemistry, 2020 (22), pp.3317-3319, which has been published in final form at https://doi.org/10.1002/ejoc.202000377. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions

Acceptance date

09/04/2020

Publication date

2020-05-08

Copyright date

2020

ISSN

1434-193X

eISSN

1099-0690

Language

en

Depositor

Prof Andrei Malkov Deposit date: 19 May 2020

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