File(s) under embargo
Reason: Publisher requirement
until file(s) become available
A mild method for electrochemical reduction of Heterocyclic N-Oxides
journal contributionposted on 20.05.2020 by Yasuaki Fukazawa, Aleksandr E Rubtsov, Andrei Malkov
Any type of content formally published in an academic journal, usually following a peer-review process.
Deoxygenation of heteroaromatic N-oxides is commonly accomplished using chemical or enzymatic methods. In this work, we report on an expedient protocol for electrochemical reduction of pyridine N-oxide derivatives under mild conditions. A diverse range of mono- and bis-N-oxides were converted into the corresponding nitrogen bases in good yields. Importantly, the method is highly selective towards N-oxides and tolerates challenging halo and nitro substituents in the heteroaromatic ring.
Russian Science Foundation for grant 18- 73-10156