A model of transient internal flow and atomization of propellant/ethanol mixtures in pressurized metered dose inhalers (pMDI)
journal contributionposted on 2018-06-18, 12:28 authored by Barzin Gavtash, Hendrik VersteegHendrik Versteeg, Graham HargraveGraham Hargrave, Benjamin J. Myatt, David Lewis, Tanya Church, G. Brambilla
This paper reports the extension to binary propellant/excipient mixtures of the multiphase model of transient internal flow and atomisation in pressurised metered dose inhalers (pMDIs) of Gavtash et al. (2017a-b) for propellant-only flows. The work considers different accounts of the effect of less volatile ethanol on the saturated vapour pressure (SVP), viscosity and surface tension of HFA-based pMDI formulations. Representation of the SVP of HFA/ethanol mixtures by Raoult’s law is compared with the empirical model developed by Gavtash et al. (2016) as well as different theoretical mixing rules for surface tension and viscosity. For initial ethanol contents ranging from 0 to 20% by mass, the temperature, pressure and spray velocity were predicted to be almost independent of ethanol concentration when using the empirical SVP model of Gavtash et al. (2016). The predicted aerosol droplet size increases with increasing concentration of ethanol. These model predictions compare favourab ly with phase Doppler anemometry (PDA) measurements of pMDI sprays. Exploration of model predictions with different mixing rules suggest that variations of the dynamic viscosity could result in 0.7 µm droplet size change, and different surface tension models yield around 1.5 µm droplet size change. The findings of this work challenge the view that the increase of droplet size is caused by the low volatility of excipients such as ethanol. Instead, attention is focused on composition-dependent viscosity and surface tension as potential controlling parameters with significant effect on the droplet size of HFA/ethanol sprays.
This research is supported by Chiesi Farmaceutici SpA.
- Mechanical, Electrical and Manufacturing Engineering
Published inAerosol Science and Technology
Pages494 - 504 (11)
CitationGAVTASH, B. ...et al., 2018. A model of transient internal flow and atomization of propellant/ethanol mixtures in pressurized metered dose inhalers (pMDI). Aerosol Science and Technology, 52(5), pp. 494-504.
Publisher© American Association for Aerosol Research. Published by Taylor & Francis
- AM (Accepted Manuscript)
Publisher statementThis work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/
NotesThis is an Accepted Manuscript of an article published by Taylor & Francis in Aerosol Science and Technology on 5 March 2018, available online: http://www.tandfonline.com/10.1080/02786826.2018.1433814.