27762877_File000052_640131153-final.pdf (2.15 MB)
Download fileA model of transient internal flow and atomization of propellant/ethanol mixtures in pressurized metered dose inhalers (pMDI)
journal contribution
posted on 2018-06-18, 12:28 authored by Barzin Gavtash, Hendrik VersteegHendrik Versteeg, Graham HargraveGraham Hargrave, Benjamin J. Myatt, David Lewis, Tanya Church, G. BrambillaThis paper reports the extension to binary propellant/excipient mixtures of the
multiphase model of transient internal flow and atomisation in pressurised metered dose inhalers (pMDIs) of Gavtash et al. (2017a-b) for propellant-only flows. The work considers different accounts of the effect of less volatile ethanol on the saturated vapour pressure (SVP), viscosity and surface tension of HFA-based pMDI formulations. Representation of the SVP of HFA/ethanol mixtures by Raoult’s law is compared with the empirical model developed by Gavtash et al. (2016) as well as different theoretical mixing rules for surface tension and viscosity. For initial ethanol contents ranging from 0 to 20% by mass, the temperature, pressure and spray velocity were predicted to be almost independent of ethanol concentration when using the empirical SVP model of Gavtash et al. (2016). The predicted aerosol
droplet size increases with increasing concentration of ethanol. These model predictions compare favourab ly with phase Doppler anemometry (PDA) measurements of pMDI sprays. Exploration of model predictions with different mixing rules suggest that variations of the dynamic viscosity could result in 0.7 µm droplet size change, and different surface tension models yield around 1.5 µm droplet size change. The findings of this work challenge the view that the increase of droplet size is caused by the low volatility of excipients such as ethanol. Instead, attention is focused on composition-dependent viscosity and surface tension as potential
controlling parameters with significant effect on the droplet size of HFA/ethanol sprays.
Funding
This research is supported by Chiesi Farmaceutici SpA.
History
School
- Mechanical, Electrical and Manufacturing Engineering
Published in
Aerosol Science and TechnologyVolume
52Issue
5Pages
494 - 504 (11)Citation
GAVTASH, B. ...et al., 2018. A model of transient internal flow and atomization of propellant/ethanol mixtures in pressurized metered dose inhalers (pMDI). Aerosol Science and Technology, 52(5), pp. 494-504.Publisher
© American Association for Aerosol Research. Published by Taylor & FrancisVersion
- AM (Accepted Manuscript)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Acceptance date
2017-12-04Publication date
2018Notes
This is an Accepted Manuscript of an article published by Taylor & Francis in Aerosol Science and Technology on 5 March 2018, available online: http://www.tandfonline.com/10.1080/02786826.2018.1433814.ISSN
0278-6826Publisher version
Language
- en