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A new method of extraction of amoxicillin using mixed reverse micelles

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journal contribution
posted on 17.12.2014, 15:08 by Sing C. Chuo, Siti H. Mohd-Setapar, Siti N. Mohamad-Aziz, Victor Starov
A completely new method of extraction of amoxicillin using solubilisation by mixed reverse micelles was proposed and the optimal conditions for the process were found. Mixed AOT-TWEEN 85 reverse micelles were used for the first time as a new approach for extraction of amoxicillin. The effects of different process variables such as AOT-TWEEN 85 molar fractions, total surfactant concentration, pH of aqueous feed solution and potassium chloride concentration during forward extraction; stripping aqueous phase pH, potassium chloride (KCl) concentration and extraction time during backward extraction were investigated and the optimal conditions were found for all mentioned parameters. With the aid of response surface methodology, the optimum conditions for forward extraction are identified as (i) 5.5:1 molar ratio of AOT/TWEEN 85, (ii) total surfactant concentration 102.57. g/L, (ii) pH 1.90, and (vi) KCl concentration 8.54. g/L. The percentage of amoxicillin solubilised in isooctane was 95.54% under these optimal conditions. On the other hand, the optimum conditions for backward extraction are identified as (i) stripping aqueous phase pH 6.58, (ii) KCl concentration 11.02. g/L, and (iii) extraction time 15. min. Under these optimal conditions, the percentage of amoxicillin recovered was 90.79%. AOT/TWEEN 85 mixed surfactant system shows a significant advantage of saving the amount of surfactant for forward extraction. The addition of non-ionic surfactant helps to preserve natural function/activity of antibiotics as compared with a pure AOT surfactant used. The optimum conditions were also found for a backward recovery of amoxicillin.

Funding

Ministry of Science, Technology and Innovation (MOSTI) and Universiti Teknologi Malaysia (UTM)

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Published in

Colloids and Surfaces A: Physicochemical and Engineering Aspects

Volume

460

Pages

137 - 144

Citation

CHUO, S.C. ... et al., 2014. A new method of extraction of amoxicillin using mixed reverse micelles. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 460 pp. 137 - 144

Publisher

© The Authors. Published by Elsevier B.V.

Version

VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution 3.0 Unported (CC BY 3.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/by/3.0/

Publication date

2014

Notes

This is an Open Access Article. It is published by Elsevier under the Creative Commons Attribution 3.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/3.0/

ISSN

0927-7757

eISSN

1873-4359

Language

en