A new simplified protocol for copper(I) alkyne–azide cycloaddition reactions using low substoichiometric amounts of copper(II) precatalysts in methanol

Buckley, Benjamin; Figueres, Maria M.P.; Khan, Amna N.; Heaney, Harry

A new simplified protocol for copper(I) alkyne–azide cycloaddition reactions using low substoichiometric amounts of copper(II) precatalysts in methanol

https://hdl.handle.net/2134/21368
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journal contribution

posted on 2016-05-26, 11:46 authored by Benjamin BuckleyBenjamin Buckley, Maria M.P. Figueres, Amna N. Khan, Harry Heaney

Copper(II) carboxylates are reduced efficiently by methanol in the presence of alkynes and form yellow alkynylcopper(I) polymeric precatalysts that are involved with azides, in the absence of added ligands, in the catalytic cycles that result in the formation of 1,4-disubstituted 1,2,3-triazoles.

Funding

The authors are grateful to The Higher Education Commission of Pakistan for a visiting fellowship (to A.N.K.) and the EU Lifelong Learning Programme for support (to M.M.P.F), and Loughborough University for research funding. B.R.B. also thanks Research Councils UK for a RCUK fellowship.

History

School

Science

Department

Chemistry

Published in

SYNLETT

Volume

27

Issue

1

Pages

51 - 56 (6)

Citation

BUCKLEY, B. ... et al., 2016. A new simplified protocol for copper(I) alkyne–azide cycloaddition reactions using low substoichiometric amounts of copper(II) precatalysts in methanol. SYNLETT, DOI: 10.1055/s-0035-1560526.

Publisher

Version

AM (Accepted Manuscript)

Publisher statement

This paper was accepted for publication in the journal SYNLETT and the definitive published version is available at https://doi.org/10.1055/s-0035-1560526