A new simplified protocol for copper(I) alkyne–azide cycloaddition reactions using low substoichiometric amounts of copper(II) precatalysts in methanol
journal contributionposted on 26.05.2016, 11:46 by Benjamin BuckleyBenjamin Buckley, Maria M.P. Figueres, Amna N. Khan, Harry Heaney
Copper(II) carboxylates are reduced efficiently by methanol in the presence of alkynes and form yellow alkynylcopper(I) polymeric precatalysts that are involved with azides, in the absence of added ligands, in the catalytic cycles that result in the formation of 1,4-disubstituted 1,2,3-triazoles.
The authors are grateful to The Higher Education Commission of Pakistan for a visiting fellowship (to A.N.K.) and the EU Lifelong Learning Programme for support (to M.M.P.F), and Loughborough University for research funding. B.R.B. also thanks Research Councils UK for a RCUK fellowship.