AFM 20180529 Manu_No Highlight.pdf (1.07 MB)
Download fileA substitution-dependent light-up fluorescence probe for selectively detecting Fe3+ ions and its cell imaging application
journal contribution
posted on 2018-10-05, 09:20 authored by Xing Feng, Ying Li, Xuewen He, Haixiang Liu, Zheng Zhao, Ryan T. Kwok, Mark ElsegoodMark Elsegood, Jacky W.Y. Lam, Ben Zhong TangDeliberate design of specific and sensitive molecular probes with distinctive physical/chemical properties for analyte sensing is of great significance. Herein, by taking advantage of the position-dependent substituent effects, an aggregation-induced emission featured iron (III) probe from ortho-substituted pyridinyl-functionalized tetraphenylethylene (TPE-o-Py) is synthesized. It displays high sensitivity and selectivity toward iron (III) detection. The recognition arises from the position isomer of ortho-substitution, and the fact that TPE-o-Py has a low acid dissociation constant (pKa) that is close to that of hydrolyzed Fe3+. Importantly, TPE-o-Py as a light-up fluorescence probe could be employed for Fe3+sensing in living cells with a pronounced red-shift in fluorescence emission.
Funding
This work was supported by the National Science Foundation of China (21602014, 21788102, and 51620105009), the Research Grants Council of Hong Kong (16308016, C6009-17G, C2014-15G, and A-HKUST605/16), the Innovation and Technology Commission (ITC-CNERC14SC01 and ITS/254/17), the Science and Technology Plan of Shenzhen (JCYJ20160229205601482, JCY20170818113602462, and JCYJ20160428150429072), and International Science & Technology Cooperation Program of Guangzhou (201704030069).
History
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- Chemistry