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A substitution-dependent light-up fluorescence probe for selectively detecting Fe3+ ions and its cell imaging application

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journal contribution
posted on 05.10.2018, 09:20 authored by Xing Feng, Ying Li, Xuewen He, Haixiang Liu, Zheng Zhao, Ryan T. Kwok, Mark ElsegoodMark Elsegood, Jacky W.Y. Lam, Ben Zhong Tang
Deliberate design of specific and sensitive molecular probes with distinctive physical/chemical properties for analyte sensing is of great significance. Herein, by taking advantage of the position-dependent substituent effects, an aggregation-induced emission featured iron (III) probe from ortho-substituted pyridinyl-functionalized tetraphenylethylene (TPE-o-Py) is synthesized. It displays high sensitivity and selectivity toward iron (III) detection. The recognition arises from the position isomer of ortho-substitution, and the fact that TPE-o-Py has a low acid dissociation constant (pKa) that is close to that of hydrolyzed Fe3+. Importantly, TPE-o-Py as a light-up fluorescence probe could be employed for Fe3+sensing in living cells with a pronounced red-shift in fluorescence emission.

Funding

This work was supported by the National Science Foundation of China (21602014, 21788102, and 51620105009), the Research Grants Council of Hong Kong (16308016, C6009-17G, C2014-15G, and A-HKUST605/16), the Innovation and Technology Commission (ITC-CNERC14SC01 and ITS/254/17), the Science and Technology Plan of Shenzhen (JCYJ20160229205601482, JCY20170818113602462, and JCYJ20160428150429072), and International Science & Technology Cooperation Program of Guangzhou (201704030069).

History

School

  • Science

Department

  • Chemistry

Published in

Advanced Functional Materials

Volume

28

Issue

35

Citation

FENG, X. ... et al, 2018. A substitution-dependent light-up fluorescence probe for selectively detecting Fe3+ ions and its cell imaging application. Advanced Functional Materials, 28 (35), 1802833.

Publisher

© Wiley

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

08/07/2018

Publication date

2018-07-08

Notes

This is the peer reviewed version of the following article: FENG, X. ... et al, 2018. A substitution-dependent light-up fluorescence probe for selectively detecting Fe3+ ions and its cell imaging application. Advanced Functional Materials, 28 (35), 1802833, which has been published in final form at https://doi.org/10.1002/adfm.201802833. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

ISSN

1616-301X

eISSN

1616-3028

Language

en

Article number

1802833