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Abnormalities of saccadic eye movements in dementia due to Alzheimer’s disease and mild cognitive impairment

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journal contribution
posted on 07.08.2019, 10:13 by Thomas DW Wilcockson, Diako Mardanbegi, Baiqiang Xia, Simon Taylor, Pete Sawyer, Hans W Gellersen, Ira Leroi, Rebecca Killick, Trevor J Crawford
Background: There is increasing evidence that people in the early stages of Alzheimer’s disease (AD) have subtle impairments in cognitive inhibition that can be detected by using relatively simple eye-tracking paradigms, but these subtle impairments are often missed by traditional cognitive assessments. People with mild cognitive impairment (MCI) are at an increased likelihood of dementia due to AD. No study has yet investigated and contrasted the MCI subtypes in relation to eye movement performance. Methods: In this work we explore whether eye-tracking impairments can distinguish between patients with the amnesic and the non-amnesic variants of MCI. Participants were 68 people with dementia due to AD, 42 had a diagnosis of aMCI, and 47 had a diagnosis of naMCI, and 92 age-matched cognitively healthy controls. Results: The findings revealed that eye-tracking can distinguish between the two forms of MCI. Conclusions: The work provides further support for eye-tracking as a useful diagnostic biomarker in the assessment of dementia.

Funding

EPSRC project EP/M006255/1 Monitoring Of Dementia using Eye Movements (MODEM)

Sir John Fisher Foundation

History

School

  • Sport, Exercise and Health Sciences

Published in

Aging

Volume

11

Issue

15

Pages

5389 - 5398

Publisher

Impact Journals, LLC

Version

VoR (Version of Record)

Rights holder

© Wilcockson et al.

Publisher statement

This is an Open Access Article. It is published by Impact Journals, LLC under the Creative Commons Attribution 3.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/3.0/

Acceptance date

19/07/2019

Publication date

2019-08-02

Copyright date

2019

eISSN

1945-4589

Language

en

Depositor

Dr Thom Wilcockson