Foster_Acetaminophen (paracetamol) induces hypothermia during acute cold stress (accepted version).pdf (204.88 kB)
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Acetaminophen (Paracetamol) induces hypothermia during acute cold stress

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posted on 02.02.2018 by Josh Foster, Alexis R. Mauger, Andrew Govus, David Hewson, Lee Taylor
Background Acetaminophen is an over-the-counter drug used to treat pain and fever, but it has also been shown to reduce core temperature (Tc) in the absence of fever. However, this side effect is not well examined in humans, and it is unknown if the hypothermic response to acetaminophen is exacerbated with cold exposure. Objective To address this question, we mapped the thermoregulatory responses to acetaminophen and placebo administration during exposure to acute cold (10 °C) and thermal neutrality (25 °C).

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Published in

Clinical Drug Investigation

Volume

37

Issue

11

Pages

1055 - 1065

Citation

FOSTER, J. ...et al., 2017. Acetaminophen (Paracetamol) induces hypothermia during acute cold stress. Clinical Drug Investigation, 37(11), pp. 1055-1065.

Publisher

© Springer

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2017-08-01

Notes

This is a post-peer-review, pre-copyedit version of an article published in Clinical Drug Investigation. The final authenticated version is available online at: https://doi.org/10.1007/s40261-017-0560-x

ISSN

1173-2563

eISSN

1179-1918

Language

en

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