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Download fileAcute effects of exercise on appetite, ad libitum energy intake and appetite-regulatory hormones in lean and overweight/obese men and women
journal contribution
posted on 2017-08-03, 12:29 authored by Jessica A. Douglas, James KingJames King, David Clayton, Andrew Jackson, Jack Sargeant, Alice ThackrayAlice Thackray, Melanie J. Davies, David StenselDavid StenselBACKGROUND: Acute exercise does not elicit compensatory changes in appetite parameters in lean individuals; however, less is known about responses in overweight individuals. This study compared the acute effects of moderate-intensity exercise on appetite, energy intake and appetite-regulatory hormones in lean and overweight/obese individuals.
METHODS: Forty-seven healthy lean (n=22, 11 females; mean(s.d.) 37.5(15.2) years; 22.4(1.5) kg·m−2) and overweight/obese (n=25, 11 females; 45.0(12.4) years, 29.2(2.9) kg·m−2) individuals completed two, 8-h trials (exercise and control). In the exercise trial, participants completed 60 min treadmill exercise (59(4)% peak oxygen uptake) at 0–1 h and rested thereafter whilst participants rested throughout the control trial. Appetite ratings and concentrations of acylated ghrelin, peptide YY (PYY) and glucagon-like peptide-1 (GLP-1) were measured at pre-determined intervals. Standardised meals were consumed at 1.5 and 4 h and an ad libitum buffet meal was provided at 7 h.
RESULTS: Exercise suppressed appetite (95% CI −3.1 to −0.5 mm, P=0.01), and elevated delta PYY (95% CI 10 to 17 pg·ml−1, P<0.001) and GLP-1 (95% CI 7 to 10 pmol·l−1, P<0.001) concentrations. Delta acylated ghrelin concentrations (95% CI −4.6 to 3.4 pg·ml−1, P=0.76) and ad libitum energy intake (95% CI −391 to 346 kJ, P=0.90) were similar between trials. Subjective and hormonal appetite parameters and ad libitum energy intake were similar between lean and overweight/obese individuals (Pgreater than or equal to0.27). The exercise-induced elevation in delta GLP-1 was greater in overweight/obese individuals (trial-by-group interaction P=0.01), whereas lean individuals exhibited a greater exercise-induced increase in delta PYY (trial-by-group interaction P<0.001).
CONCLUSIONS: Acute moderate-intensity exercise transiently suppressed appetite and increased PYY and GLP-1 in the hours after exercise without stimulating compensatory changes in appetite in lean or overweight/obese individuals. These findings underscore the ability of exercise to induce a short-term energy deficit without any compensatory effects on appetite regardless of weight status.
Funding
The research was supported by the National Institute for Health Research (NIHR) Leicester Biomedical Research Centre.
History
School
- Sport, Exercise and Health Sciences
Published in
International Journal of ObesityVolume
41Issue
12Pages
1737–1744Citation
DOUGLAS, J.A. ... et al, 2017. Acute effects of exercise on appetite, ad libitum energy intake and appetite-regulatory hormones in lean and overweight/obese men and women. International Journal of Obesity, 41(12), pp.1737-1744.Publisher
© The Authors. Published by Nature Publishing GroupVersion
- AM (Accepted Manuscript)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Acceptance date
2017-07-17Publication date
2017-08-03Copyright date
2017Notes
This is an Open Access Article. It is published by Nature Publishing Group under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND). Full details of this licence are available at: http://creativecommons.org/licenses/by-nc-nd/4.0/ISSN
0307-0565eISSN
1476-5497Publisher version
Language
- en