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Adaptive concentration control of cooling and antisolvent crystallization with laser backscattering measurement

journal contribution
posted on 14.07.2009, 13:25 authored by Xing Yi Woo, Zoltan NagyZoltan Nagy, Reginald B. H. Tan, Richard D. Braatz
The paper presents a thorough simulation and experimental evaluation of the concentration control approach for batch and semibatch crystallization. The sensitivity of concentration feedback control is assessed in the case of various disturbances that result in excessive nucleation events. The enhanced robustness of the concentration control is demonstrated against the widely used direct operation approach, which directly implements the temperature or anti-solvent addition rate versus time. Two adaptive supersaturation control approaches are proposed that employ measurement of the number of particle counts per unit time provided by in-situ laser backscattering, to detect the onset of nucleation and adapt the operating curve accordingly, further enhancing the robustness of the approach. Simulation and experimental results indicate that adaptive concentration control is robust to variations in the nucleation, growth, or dissolution rates due to scale-up or other changes in the process conditions.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Citation

WOO, X.Y. ... et al, 2009. Adaptive concentration control of cooling and antisolvent crystallization with laser backscattering measurement. Crystal Growth and Design, 9 (1), pp. 182-191

Publisher

© American Chemical Society

Version

NA (Not Applicable or Unknown)

Publication date

2009

Notes

This article is Restricted Access. It was published in the journal, Crystal Growth and Design [© American Chemical Society] and is available from: http://pubs.acs.org/doi/abs/10.1021/cg800131r

ISSN

1528-7483

Language

en

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