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Aerobic exercise training in healthy postmenopausal women: effects of hormone therapy

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posted on 18.03.2016, 12:02 by Emma ODonnellEmma ODonnell, Lori D. Kirwan, Jack M. Goodman
OBJECTIVE: We investigated the influence of hormone therapy (HT) on submaximal central and peripheral function in healthy postmenopausal women after 12 weeks of endurance training. METHODS: A randomized, double-blind, placebo-controlled study in a research and clinical facility was conducted. All participants (N = 23) underwent 12 weeks of aerobic exercise training (walking 5 d/wk at 70%-80% peak heart rate [HR]). Eleven participants received HT; 12 received placebo. HT consisted of daily 17beta-estradiol (1 mg) with cyclic micronized progesterone (200 mg) or placebo for 10 days per month. Participants were tested before and after exercise training. Primary outcome measures were submaximal stroke volume, cardiac output, and total peripheral resistance measured during cycling at 30W, 45W, and 60W. Secondary outcome measures were ventilatory threshold, peak oxygen uptake (VO2 peak), and resting and peak-ischemic calf blood flow. RESULTS: At baseline, HT and placebo groups were similar (P > 0.05) in age (mean +/- SEM, 57 +/- 1 y), height (162 +/- 2 cm), weight (72 +/- 4 kg), VO2 peak (21.5 +/- 1.4 mL . kg . min), and all cardiovascular measures. Posttraining oxygen consumption and HR decreased (P < 0.05) within groups during each submaximal exercise workload. Stroke volume, cardiac output, and total peripheral resistance remained unaltered (P > 0.05). VO2 peak and oxygen consumption at the ventilatory threshold increased (P < 0.05) within groups. Resting and postischemic blood flow were unaltered. HT did not influence any of the cardiovascular responses. CONCLUSIONS: These findings suggest that in healthy postmenopausal women, 12 weeks of aerobic training is effective in eliciting favorable cardiovascular adaptations, regardless of the presence of short-term HT.

Funding

This work was supported by the Heart and Stroke Foundation of Ontario Grant NA336

History

School

  • Sport, Exercise and Health Sciences

Published in

Menopause (New York, N.Y.)

Volume

16

Issue

4

Pages

770 - 776

Citation

O'DONNELL, E., KIRWAN, L.D. and GOODMAN, J.M., 2009. Aerobic exercise training in healthy postmenopausal women: effects of hormone therapy.. Menopause, 16(4), pp. 770-776.

Publisher

© Lippincott, Williams & Wilkins for the North American Menopause Society

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2009

Notes

This is a non-final version of an article published in final form in O'DONNELL, E., KIRWAN, L.D. and GOODMAN, J.M., 2009. Aerobic exercise training in healthy postmenopausal women: effects of hormone therapy.. Menopause, 16(4), pp. 770-776.

ISSN

1072-3714

eISSN

1530-0374

Language

en