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Afferent thermosensory function in relapsing-remitting multiple sclerosis following exercise-induced increases in body temperature

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posted on 01.06.2017, 15:12 authored by Davide Filingeri, Georgia K. Chaseling, Phu Hoang, Michael Barnett, Scott L. Davis, Oliver E. Jay
In multiple sclerosis (MS), increases in body temperature result in transient worsening of clinical symptoms (heat-sensitivity/Uhthoff's phenomenon). While the impact of heat-sensitivity on efferent physiological function has been investigated, the effects of heat stress on afferent sensory function in MS are unknown. Hence, we quantified afferent thermosensory function in MS following exercise-induced increases in body temperature with a novel quantitative sensory test. Eight relapsing-remitting MS patients (3M/5F; 51.4 ± 9.1 y; EDSS score: 2.8 ± 1.1) and 8 age-matched controls (CTR; 5M/3F; 47.4 ± 9.1 y) rated perceived magnitude of two cold (26; 22°C) and warm (34; 38°C) stimuli applied to the dorsum of the hand, pre and post 30-min cycling in the heat (30°C air; 30% RH). Exercise produced similar increases in mean body temperature in MS (+0.39°C [95%CI: +0.21, +0.53] P = 0.001) and CTR (+0.41°C [95%CI: +0.25, +0.58] P = 0.001). These changes were sufficient to significantly decrease thermosensitivity to all cold (26°C stimulus: -9.1% [95%CI: -17.0, -1.5], P = 0.006; 22°C stimulus: -10.6% [95%CI: -17.3, -3.7], P = 0.027), but not warm, stimuli in MS. Contrariwise, CTR showed sensitivity reductions to colder stimuli only (22°C stimulus: -9.7% [95%CI: -16.4, -3.1], P = 0.011). The observation that reductions in thermal-sensitivity in MS were confined to the myelinated cold-sensitive pathway, and extended across a wider (including milder/colder) temperature range than what is observed in CTR, provides novel evidence on the impact of rising body temperature on afferent neural function in MS. Also, our findings support the use of our novel approach to investigate afferent sensory function in MS during heat stress. This article is protected by copyright. All rights reserved.

Funding

This work was supported by Multiple Sclerosis Research Australia (incubator grant 14-009 to O.J., M.B., P.H. and S.L.D.) and by the Australian Government, Department of Education (Endeavor Post-Doctoral Research Fellowship to D.F.).

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Published in

Experimental Physiology

Volume

102

Issue

8

Pages

887-893

Citation

FILINGERI, D. ... et al, 2017. Afferent thermosensory function in relapsing-remitting multiple sclerosis following exercise-induced increases in body temperature. Experimental Physiology, 102(8), pp.887-893.

Publisher

Wiley © The Authors © The Physiological Society

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

04/05/2017

Publication date

2017-05-10

Notes

This is the peer reviewed version of the following article: FILINGERI, D. ... et al, 2017. Afferent thermosensory function in relapsing-remitting multiple sclerosis following exercise-induced increases in body temperature. Experimental Physiology, 102(8), pp.887-893, which has been published in final form at http://dx.doi.org/10.1113/EP086320. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

ISSN

0958-0670

eISSN

1469-445X

Language

en

Location

England

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