C5TB02174J.pdf (1.91 MB)
Download fileAlginate–lavender nanofibers with antibacterial and anti-inflammatory activity to effectively promote burn healing
journal contribution
posted on 2016-02-23, 13:40 authored by Hadi Hajiali, Maria Summa, Debora Russo, Andrea Armirotti, Virgilio Brunetti, Rosalia Bertorelli, Athanassia Athanassiou, Elisa MeleElisa MeleOne of the current challenges in wound care is the development of multifunctional dressings that can both protect the wound from external agents and promote the regeneration of the new tissue. Here, we show the combined use of two naturally derived compounds, sodium alginate and lavender essential oil, for the production of bioactive nanofibrous dressings by electrospinning, and their efficacy for the treatment of skin burns induced by midrange ultraviolet radiation (UVB). We demonstrate that the engineered dressings reduce the risk of microbial infection of the burn, since they stop the growth of Staphylococcus aureus. Furthermore, they are able to control and reduce the inflammatory response that is induced in human foreskin fibroblasts by lipopolysaccharides, and in rodents by UVB exposure. In particular, we report a remarkable reduction of pro-inflammatory cytokines when fibroblasts or animals are treated with the alginate-based nanofibers. The down-regulation of cytokines production and the absence of erythema on the skin of the treated animals confirm that the here described dressings are promising as advanced biomedical devices for burn management.
History
School
- Aeronautical, Automotive, Chemical and Materials Engineering
Department
- Materials
Published in
Journal of Materials Chemistry BVolume
4Issue
9Pages
1686 - 1695Citation
HAJIALI, H. ...et al., 2016. Alginate-lavender nanofibers with antibacterial and anti-inflammatory activity to effectively promote burn healing. Journal of Materials Chemistry B, 4 (9), pp. 1686-1695.Publisher
© Royal Society of ChemistryVersion
- AM (Accepted Manuscript)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Acceptance date
2016-02-03Publication date
2016-02-04Notes
This paper was accepted for publication in the journal Journal of Materials Chemistry B and the definitive published version is available at http://dx.doi.org/10.1039/C5TB02174JISSN
2050-750XeISSN
2050-7518Publisher version
Language
- en