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An asymmetric synthesis of trans-fused butyrolactones from endoperoxides

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posted on 09.01.2014 by Joshua Priest, Mark R. Longland, Mark Elsegood, Marc Kimber
The intermolecular addition of 1,3-dicarbonyl equivalents to endoperoxides in the presence of an organocatalyst yields trans-fused butyrolactones in high yield and enantioselectivities. This methodology expands the synthetic utility of endoperoxides and further underlines their potential as sources of oxygen functionality for natural and non-natural product target synthesis.

History

School

  • Science

Department

  • Chemistry

Citation

PRIEST, J. ... et al, 2013. An asymmetric synthesis of trans-fused butyrolactones from endoperoxides. Journal of Organic Chemistry, 78 (7), pp. 3476 - 3481

Publisher

© American Chemical Society

Version

AM (Accepted Manuscript)

Publication date

2013

Notes

This article is closed access until April 2014, it was published in the serial Journal of Organic Chemistry [© American Chemical Society]. The definitive version is available at: http://dx.doi.org/10.1021/jo400177j

ISSN

0022-3263

Language

en

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