An asymmetric synthesis of trans-fused butyrolactones from endoperoxides
journal contributionposted on 09.01.2014 by Joshua Priest, Mark R. Longland, Mark Elsegood, Marc Kimber
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The intermolecular addition of 1,3-dicarbonyl equivalents to endoperoxides in the presence of an organocatalyst yields trans-fused butyrolactones in high yield and enantioselectivities. This methodology expands the synthetic utility of endoperoxides and further underlines their potential as sources of oxygen functionality for natural and non-natural product target synthesis.