Lactone paper JOC Lupin.pdf (647.04 kB)
Download fileAn asymmetric synthesis of trans-fused butyrolactones from endoperoxides
journal contribution
posted on 2014-01-09, 13:54 authored by Joshua Priest, Mark R. Longland, Mark ElsegoodMark Elsegood, Marc KimberMarc KimberThe intermolecular addition of 1,3-dicarbonyl equivalents to endoperoxides in the presence of an organocatalyst yields trans-fused butyrolactones in high yield and enantioselectivities. This methodology expands the synthetic utility of endoperoxides and further underlines their potential as sources of oxygen functionality for natural and non-natural product target synthesis.
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