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An exploration of the role of exercise in modulating breast cancer progression in vitro (a systematic review and meta-analysis)

journal contribution
posted on 12.01.2021, 11:55 by Marie-Juliet Brown, Mhairi Morris, Liz Akam
Background: Breast cancer is the most prevalent cancer in women worldwide. In the UK, approximately 5% of all breast cancers are already metastatic at the time of diagnosis. An abundance of literature shows exercise can have beneficial effects on the outcome and prognosis of breast cancer patients, yet the molecular mechanisms remain poorly understood. There are several in vitro models that aim to recapitulate the response of breast cancer to exercise in vivo: this systematic review and meta-analysis summarises the existing literature. Methods: The following search terms were used to conduct a systematic literature search using a collection of databases (last search performed May 2020): 'in vitro' and 'exercise' and 'breast cancer'. Only studies that investigated the effects of exercise on breast cancer in vitro were included. Standardised mean differences (SMD) were calculated to determine pooled effect sizes. Results: This meta-analysis has successfully demonstrated that various identified exercise interventions on breast cancer cells in vitro significantly reduced breast cancer cell viability, proliferation, and tumourigenic potential (SMD: -1.76, p = 0.004, SMD: -2.85, p = 0.003 and SMD: -3.15, p = 0.0008, respectively). A clear direction of effect was found with exercise on breast cancer cell migration in vitro, however this effect was not significant (SMD: -0.62, p = 0.317). Conclusion: To our knowledge, this is the first meta-analysis and systematic review investigating and summarising literature on exercise and breast cancer in vitro, highlighting models used and priority areas for future research focus.

History

School

  • Sport, Exercise and Health Sciences

Published in

American Journal of Physiology-Cell Physiology

Volume

320

Issue

3

Pages

C253-C263

Publisher

American Physiological Society

Version

AM (Accepted Manuscript)

Rights holder

© 2020, American Journal of Physiology-Cell Physiology

Publisher statement

This paper was accepted for publication in the journal American Journal of Physiology-Cell Physiology and the definitive published version is available at https://doi.org/10.1152/ajpcell.00461.2020

Acceptance date

18/12/2020

Publication date

2021-03-02

Copyright date

2021

ISSN

0363-6143

eISSN

1522-1563

Language

en

Depositor

Dr Liz Akam Deposit date: 8 January 2021

Article number

ajpcell.00461.2020