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An in‐vitro evaluation of the characteristics of zein‐based films for the release of lactobionic acid and the effects of oleic acid

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journal contribution
posted on 13.09.2021, 13:33 by Alessandro Coroli, Roberta Romano, Andrea Saccani, Noura Raddadi, Elisa MeleElisa Mele, Leno Mascia
Lactobionic acid (LBA) is widely used in different industrial sectors owing to its biocom-patibility characteristics as well as antioxidant and antimicrobial properties. In this study, mixtures of the protein zein with LBA and with the addition of oleic acid (OA) as a ternary system were investigated as drug delivery films for the release of LBA. The chosen combinations exploit the vast difference in water solubility between LBA and the other two components (zein and OA). DSC ther-mograms and dynamic mechanical spectra, alongside electron microscopy images, were used to describe the microstructural features of the films and were found to provide insights for the release of LBA from the two examined zein‐based films immersed in an aqueous physiological solution. For both film systems, a burst release behavior was observed, followed by a rapid and total extraction of LBA. The required immersion time for the total extraction of LBA was greatly reduced when oleic acid was added to the precursor solution mixture for producing the films. The LBA released from the zein‐based films was found to exhibit both the expected antioxidant properties as well as exerting bacteriostatic effects towards Escherichia coli and Staphylococcus epidermidis.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Materials

Published in

Polymers

Volume

13

Issue

11

Publisher

MDPI

Version

VoR (Version of Record)

Rights holder

© The authors

Publisher statement

This is an Open Access Article. It is published by MDPI under the Creative Commons Attribution 4.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/

Acceptance date

28/05/2021

Publication date

2021-05-31

Copyright date

2021

eISSN

2073-4360

Language

en

Depositor

Dr Elisa Mele. Deposit date: 7 September 2021

Article number

1826