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An investigation into the inactivation kinetics of hydrogen peroxide vapor against clostridium difficile endospores

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journal contribution
posted on 17.11.2016 by Danish Malik, C.M. Shaw, Gilbert Shama, Martha R.J. Clokie, Chris Rielly
C. difficile spores are resistant to routine cleaning agents and are able to survive on inanimate surfaces for long periods of time. There is increasing evidence of the importance of the clinical environment as a reservoir for pathogenic agents and as a potential source of healthcare-associated infections (HCAIs). In this context, to reduce the risk of cross-transmission, terminal disinfection of hospital wards and isolation rooms using hydrogen peroxide vapor (HPV) is attracting attention. Spores of C. difficile (ribotype 027) were exposed to constant concentrations of HPV ranging between 11 and 92 mg m−3 (ppm) for a range of exposure times in a specially designed chamber. The inactivation data thus obtained was fitted using the modified Chick–Watson inactivation model to obtain decimal reduction values (D values). D values ranged from 23 to 1.3 min at HPV concentrations of 11 and 92 ppm, respectively. We present a simple mathematical model based on the inactivation kinetic data obtained here to estimate the efficacy of commercial HPV processes used in healthcare environmental decontamination. C. difficile spores showed linear inactivation kinetics at steady HPV concentrations ranging between 10 and 90 ppm. The data obtained here was used to provide estimates of the inactivation efficacy of commercial HPV process cycles, which employ unsteady HPV concentrations during the decontamination process.

Funding

The authors would like to acknowledge EPSRC support for this work (Grant no. EP=D039614=1) via the Health and Care Infrastructure Research and Innovation Centre (HaCIRIC).

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Published in

Chemical Engineering Communications

Volume

203

Issue

12

Pages

1615 - 1624

Citation

MALIK, D.J. ... et al, 2016. An investigation into the inactivation kinetics of hydrogen peroxide vapor against clostridium difficile endospores. Chemical Engineering Communications, 203 (12), pp. 1615-1624.

Publisher

Taylor & Francis /© The Authors

Version

VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

23/08/2016

Publication date

2016-10-27

Copyright date

2016

Notes

This article is open access it was published by Taylor and Francis and distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/).

ISSN

0098-6445

eISSN

1563-5201

Language

en

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