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An oxygen transport model of human bone marrow for hemolytic sickle cell anemia
journal contributionposted on 2017-11-07, 09:53 authored by Ahsan IslamAhsan Islam, R. Kumar
The human bone marrow (BM) is a complicated tissue with intricate vascular and heterogeneous extravascular (tissue) architecture. Oxygen is an important modulator of differentiation and proliferation of the BM hematopoietic cells under normal and pathological conditions. Currently, due to the inaccessibility of the BM, it is not possible to measure the spatial distribution of the oxygen tension (concentration) levels in the tissue. Thus, the present treatise utilizes mathematical modeling to offer a greater insight on the effects of oxygen on the BM cellular components. Here, we present simulation results that are correlated with known in vivo data of BM along with proposing a model for the two state description of allosteric hemoglobin molecule under hemolytic sickle cell anemia condition of BM.
Commonwealth Scholarship Commission.
- Aeronautical, Automotive, Chemical and Materials Engineering
- Chemical Engineering
Published inJournal of Chemical Engineering
Pages7 - 7
CitationISLAM, M. and KUMAR, R., 2006. An oxygen transport model of human bone marrow for hemolytic sickle cell anemia. Journal of Chemical Engineering (Bangladesh), 24 (1), pp.7-13.
PublisherBangladesh Journals Online
- AM (Accepted Manuscript)
Publisher statementThis work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/