An oxygen transport model of human bone marrow for hemolytic sickle cell anemia

The human bone marrow (BM) is a complicated tissue with intricate vascular and heterogeneous extravascular (tissue) architecture. Oxygen is an important modulator of differentiation and proliferation of the BM hematopoietic cells under normal and pathological conditions. Currently, due to the inaccessibility of the BM, it is not possible to measure the spatial distribution of the oxygen tension (concentration) levels in the tissue. Thus, the present treatise utilizes mathematical modeling to offer a greater insight on the effects of oxygen on the BM cellular components. Here, we present simulation results that are correlated with known in vivo data of BM along with proposing a model for the two state description of allosteric hemoglobin molecule under hemolytic sickle cell anemia condition of BM.