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An oxygen transport model of human bone marrow for hemolytic sickle cell anemia

journal contribution
posted on 07.11.2017, 09:53 authored by Ahsan IslamAhsan Islam, R. Kumar
The human bone marrow (BM) is a complicated tissue with intricate vascular and heterogeneous extravascular (tissue) architecture. Oxygen is an important modulator of differentiation and proliferation of the BM hematopoietic cells under normal and pathological conditions. Currently, due to the inaccessibility of the BM, it is not possible to measure the spatial distribution of the oxygen tension (concentration) levels in the tissue. Thus, the present treatise utilizes mathematical modeling to offer a greater insight on the effects of oxygen on the BM cellular components. Here, we present simulation results that are correlated with known in vivo data of BM along with proposing a model for the two state description of allosteric hemoglobin molecule under hemolytic sickle cell anemia condition of BM.

Funding

Commonwealth Scholarship Commission.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Published in

Journal of Chemical Engineering

Volume

24

Pages

7 - 7

Citation

ISLAM, M. and KUMAR, R., 2006. An oxygen transport model of human bone marrow for hemolytic sickle cell anemia. Journal of Chemical Engineering (Bangladesh), 24 (1), pp.7-13.

Publisher

Bangladesh Journals Online

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2006

ISSN

2221-7436

eISSN

2408-8617

Language

en

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