Loughborough University

File(s) under permanent embargo

Reason: This item is currently closed access.

Anharmonic interaction signals for acoustic detection of analyte

journal contribution
posted on 2014-09-09, 14:20 authored by Sourav GhoshSourav Ghosh, Victor P. Ostanin, Ashwin A. Seshia
The challenges with frequency-based acoustic detection systems in sensitive, selective, and reliable quantitative estimation of surface-bound analyte are well-known. These systems are traditionally used in their linear incarnations; i.e., the measurement frequency is the same as the driving frequency. However, it was found in this work that interactions of adsorbents with sensor surface show significant anharmonicity even at low drive amplitudes. In particular, using streptavidin-coated polystyrene microbeads on an oscillating quartz surface in air, it has been demonstrated through modeling and experiments that the anharmonic signal from microparticle to surface interaction is significantly higher relative to that from bare quartz and orders of magnitude higher than relative shifts in resonant frequency. The signal is proportional to the number of microparticles and holds a well-defined functional relationship with the amplitude of oscillation, distinct to the nature of interaction with the surface for a given analyte. This approach, thus, can be used for ultrasensitive and quantitative detection of surface adsorbents and characterization of different kinds of surface interactions, distinguishing specific from nonspecific adsorbents. The modeling also reveals a direct functional relationship between the measured anharmonic signal and the interaction potential of the adsorbent with the surface. © 2010 American Chemical Society.


This project was funded in part by the U.S. Army Soldier Systems Center and the Cambridge Commonwealth Trust.



  • Mechanical, Electrical and Manufacturing Engineering

Published in

Analytical Chemistry






3929 - 3935


GHOSH, S.K., OSTANIN, V.P. and SESHIA, A.A., 2010. Anharmonic interaction signals for acoustic detection of analyte. Analytical Chemistry, 82 (9), pp. 3929 - 3935


© American Chemical Society


  • AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date



This article is closed access.




  • en