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Anion binding in water at lanthanide centres: from structure and selectivity to signalling and sensing

journal contribution
posted on 15.09.2015, 12:54 authored by Stephen ButlerStephen Butler, David Parker
Reversible anion binding at lanthanide centres in aqueous media has emerged as an effective means of signalling and sensing the presence of selected anions. The constitution and configuration of a wide range of anion adducts has been defined by X-ray analyses and NMR methods, and both chelating and monodentate binding modes characterised. Variation of the lanthanide ion modulates charge density, and ligand modification allows alteration of both the peripheral electrostatic gradient and the local steric demand at the metal centre. Thus, selectivity for a target anion can be engineered, and the affinity constant modulated to target the desired concentration range. Changes in anion concentration can be monitored rapidly, accurately and with high spatial resolution using optical emission spectroscopy and microscopy, facilitating the measurement of anions such as bicarbonate, lactate, citrate and urate in a variety of bio-fluids.

Funding

We thank the ERC for support (FCC 266804)

History

School

  • Science

Department

  • Chemistry

Published in

CHEMICAL SOCIETY REVIEWS

Volume

42

Issue

4

Pages

1652 - 1666 (15)

Citation

BUTLER, S.J. and PARKER, D., 2013. Anion binding in water at lanthanide centres: from structure and selectivity to signalling and sensing. Chemical Society Reviews, 42 (4), pp. 1652 - 1666.

Publisher

© The Royal Society of Chemistry

Version

VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2013

Notes

This article is closed access.

ISSN

0306-0012

Language

en

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