Butler_cplu.202000567.pdf (4.05 MB)

Anion receptors for the discrimination of ATP and ADP in biological media

Download (4.05 MB)
journal contribution
posted on 27.10.2020, 14:50 by Stephen Butler, Katrina A Jolliffe
© 2020 The Authors. Published by Wiley-VCH GmbH The design and synthesis of molecular receptors for the selective binding of nucleoside phosphate anions (e. g. ATP, ADP, GTP, GDP, UDP) in aqueous media at physiological pH is a valuable research endeavour, which could lead to new sensing tools for biomedical and drug discovery research. However, this target is very challenging due to similarities in anion size, structure and charge. This Minireview provides an account of the development of receptors capable of discriminating between ATP and ADP, and their utilisation in biological sensing applications. Particular focus is given to the application of receptors for the determination of ATP or ADP concentrations in biological media, tracking ATP levels (or the ATP/ADP ratio) in cells using fluorescence microscopy, or real-time monitoring of enzyme reactions involving ATP and ADP in vitro.

History

School

  • Science

Department

  • Chemistry

Published in

ChemPlusChem

Volume

86

Issue

1

Pages

59-70

Publisher

Wiley

Version

VoR (Version of Record)

Rights holder

© The authors

Publisher statement

This is an Open Access Article. It is published by Wiley under the Creative Commons Attribution 4.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/

Acceptance date

30/09/2020

Publication date

2020-10-15

Copyright date

2021

ISSN

2192-6506

eISSN

2192-6506

Language

en

Depositor

Dr Stephen Butler Deposit date: 27 October 2020

Licence

Exports