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Antisolvent crystallization of telmisartan using stainless-steel micromixing membrane contactors

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posted on 2024-02-29, 17:19 authored by Matthew John Bennett, Elina Beveniou, Alex Robin Kerr, Marijana DragosavacMarijana Dragosavac
Controlled continuous crystallization of the active pharmaceutical ingredient (API) telmisartan (TEL) has been conducted from TEL/DMSO solutions by antisolvent crystallization in deionized water using membrane micromixing contactors. The purpose of this work was to test stainless-steel membranes with ordered 10 μm pores spaced at 200 μm in a stirred-cell (batch, LDC-1) and crossflow (continuous, AXF-1) system for TEL formation. By controlling the feed flow rate of the API and solvent, through the membrane pores as well as the antisolvent flow, it was possible to tightly control the micromixing and with that to control the crystal nucleation and growth. Batch crystallization without the membrane resulted in an inhomogeneous crystallization process, giving a mixture of crystalline and amorphous TEL materials. The rate of crystallization was controlled with a higher DMSO content (4:1 DMSO/DI water), resulting in slower crystallization of the TEL material. Both membrane setups, stirred batch and the crossflow, yielded the amorphous TEL particles when deionized water was used, while a crystalline material was produced when a mixture of DI water and DMSO was used.

Funding

TAILORING THE MICRO- AND MESO-POROSITY OF SPHERICAL SILICA PARTICLES USING NANO/MICROBUBBLES AS TEMPLATES

Engineering and Physical Sciences Research Council

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History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Published in

Crystal Growth & Design

Volume

23

Issue

5

Pages

3720 - 3730

Publisher

American Chemical Society

Version

  • VoR (Version of Record)

Rights holder

© The Authors

Publisher statement

This is an Open Access Article. It is published by the American Chemical Society under the Creative Commons Attribution 4.0 International Licence (CC BY). Full details of this licence are available at: https://creativecommons.org/licenses/by/4.0/

Publication date

2023-04-24

Copyright date

2023

ISSN

1528-7483

eISSN

1528-7505

Language

  • en

Depositor

Deposit date: 28 February 2024

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