Approaches for manufacture, formulation, targeted delivery and controlled release of phage-based therapeutics
A future successful bacteriophage industry requires
development of robust scalable manufacturing platforms for
upstream production of high phage titres and their downstream
purification and concentration whilst achieving processing
yields en route. Development of a broadly applicable process
flow sheet employing well-characterised unit operations with
knowledge of their critical process parameters is beginning to
emerge. A quality-by-design approach is advocated for the
development of cost-effective phage production platforms.
The use of on-line and at-line process analytical tools for
process monitoring, control and quality assurance are
discussed. Phage biophysical characterisation tools allowing
rational development of liquid formulations and dry powder
forms are presented. Recent innovations in phage
encapsulation methods highlight the potential innovation
opportunities in this research space that could have significant
impact on the future prospects of this industry.
History
School
- Aeronautical, Automotive, Chemical and Materials Engineering
Department
- Chemical Engineering
Published in
Current Opinion in BiotechnologyVolume
68Pages
262 - 271Publisher
Elsevier BVVersion
- VoR (Version of Record)
Rights holder
© ElsevierPublication date
2021-03-18Copyright date
2021ISSN
0958-1669Publisher version
Language
- en
Depositor
Dr Danish Malik. Deposit date: 20 March 2021Usage metrics
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