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Association analysis of TNFR2, VDR, A2M, GSTT1, GSTM1, and ACE genes with rheumatoid arthritis in South Asians and Caucasians of East Midlands in the United Kingdom

journal contribution
posted on 27.06.2014, 12:55 by Anant M. Ghelani, Ash Samanta, Adrian C. Jones, Sarabjit MastanaSarabjit Mastana
Genetic associations of TNFR2, VDR (Bsm I and Fok I), A2M, GSTT , GSTM and ACE in South Asian and Caucasian patients with rheumatoid arthritis (RA) were assessed in this study. DNA samples from South Asians (134 cases, 149 controls) and Caucasians (137 cases, 150 controls) from the East Midlands of the United Kingdom were genotyped for seven polymorphisms. All cases were rheumatoid-factor positive. Significant genetic associations were observed with TNFR2 R-R (OR = 3.16, CI 1.20-9.26, P < 0.05), A2M 1-1 (OR = 2.09, CI 1.21-3.64, P < 0.05) and GST Tnull (OR = 1.97, CI 1.07-3.68, P < 0.05) among Caucasian patients. In South Asians, VDR Bsm I B-B genotype (OR = 2.08, CI 1.23-3.52, P < 0.05), A2M 2-2 genotype (OR = 3.99, CI 1.19-17.18, P < 0.05), and GST Tnull genotype (OR = 2.81, CI 1.40-5.77, P < 0.002) genotypes were associated with RA. In the majority of cases, recessive and multiplicative modes of inheritance explained the observed associations. This study demonstrates that ethnicity affects the genetic associations in RA. © 2010 Springer-Verlag.

History

School

  • Sport, Exercise and Health Sciences

Published in

Rheumatology International

Volume

31

Issue

10

Pages

1355 - 1361

Citation

GHELANI, A.M. ... et al, 2011. Association analysis of TNFR2, VDR, A2M, GSTT1, GSTM1, and ACE genes with rheumatoid arthritis in South Asians and Caucasians of East Midlands in the United Kingdom. Rheumatology International, 31 (10), pp. 1355 - 1361

Publisher

© Springer-Verlag

Version

VoR (Version of Record)

Publication date

2011

Notes

This article is closed access.

ISSN

0172-8172

eISSN

1437-160X

Language

en