JOEM-OA inflamamtion_depression_submitted version_LUPIN.pdf (389.88 kB)

Association between depression, lung function and inflammatory markers in patients with asthma and occupational asthma

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journal contribution
posted on 04.04.2019, 13:01 by Nicola Paine, Maryann F. Joseph, Simon L. Bacon, Cassandre A. Julien, Andre Cartier, Blaine Ditto, Helene Favreau, Kim L. Lavoie
Objective: Depression is associated with autonomic and immune dysregulation, yet this remains poorly explored in asthma. We assessed associations between depressive disorder, lung function, and inflammatory markers in patients under investigation for occupational asthma (OA). Methods: 112 patients under investigation for OA (60% men) underwent a psychiatric interview to assess depressive disorder, and spirometry, a methacholine test, sputum induction and specific inhalation challenge (SIC) to assess OA. Blood and sputum inflammatory markers were assessed. Results: There was a statistically significant association between depressive disorder (p=.0195) and FEV1 responses, with the drop in FEV1 post-SIC smaller in patients with OA and depression, versus OA with no depression, (p < .001). Conclusions: The presence of depressive disorder may influence FEV1 in patients with OA, which may be via autonomic pathways. However, further studies are warranted in order to determine the mechanisms which underlie these effects.

Funding

Funding support for this study was provided by the Institut de recherche en santé et sécurité au travail (IRSST) (KLL) and the Asthma in the Workplace Center (KLL, SLB).

History

School

  • Sport, Exercise and Health Sciences

Published in

Journal of Occupational and Environmental Medicine

Volume

61

Issue

6

Pages

453 - 460

Citation

PAINE, N.J. ... et al., 2019. Association between depression, lung function and inflammatory markers in patients with asthma and occupational asthma. Journal of Occupational and Environmental Medicine, 61 (6), pp.453–460.

Publisher

Lippincott, Williams & Wilkins

Version

AM (Accepted Manuscript)

Rights holder

© American College of Occupational and Environmental Medicine

Publisher statement

This is a non-final version of an article published in final form in Journal of Occupational and Environmental Medicine, 61 (6), pp.453–460, doi: 10.1097/JOM.0000000000001562.

Acceptance date

11/02/2019

Publication date

2019-06-01

Copyright date

2019

ISSN

1076-2752

Language

en

Exports

Loughborough Publications

Exports