JOEM-OA inflamamtion_depression_submitted version_LUPIN.pdf (389.88 kB)
Download fileAssociation between depression, lung function and inflammatory markers in patients with asthma and occupational asthma
journal contribution
posted on 2019-04-04, 13:01 authored by Nicola PaineNicola Paine, Maryann F. Joseph, Simon L. Bacon, Cassandre A. Julien, Andre Cartier, Blaine Ditto, Helene Favreau, Kim L. LavoieObjective: Depression is associated with autonomic and immune dysregulation, yet this
remains poorly explored in asthma. We assessed associations between depressive
disorder, lung function, and inflammatory markers in patients under investigation for
occupational asthma (OA).
Methods: 112 patients under investigation for OA (60% men) underwent a psychiatric
interview to assess depressive disorder, and spirometry, a methacholine test, sputum
induction and specific inhalation challenge (SIC) to assess OA. Blood and sputum
inflammatory markers were assessed.
Results: There was a statistically significant association between depressive disorder
(p=.0195) and FEV1 responses, with the drop in FEV1 post-SIC smaller in patients with OA
and depression, versus OA with no depression, (p < .001).
Conclusions: The presence of depressive disorder may influence FEV1 in patients with
OA, which may be via autonomic pathways. However, further studies are warranted in
order to determine the mechanisms which underlie these effects.
Funding
Funding support for this study was provided by the Institut de recherche en santé et sécurité au travail (IRSST) (KLL) and the Asthma in the Workplace Center (KLL, SLB).
History
School
- Sport, Exercise and Health Sciences
Published in
Journal of Occupational and Environmental MedicineVolume
61Issue
6Pages
453 - 460Citation
PAINE, N.J. ... et al., 2019. Association between depression, lung function and inflammatory markers in patients with asthma and occupational asthma. Journal of Occupational and Environmental Medicine, 61 (6), pp.453–460.Publisher
Lippincott, Williams & WilkinsVersion
- AM (Accepted Manuscript)
Rights holder
© American College of Occupational and Environmental MedicinePublisher statement
This is a non-final version of an article published in final form in Journal of Occupational and Environmental Medicine, 61 (6), pp.453–460, doi: 10.1097/JOM.0000000000001562.Acceptance date
2019-02-11Publication date
2019-06-01Copyright date
2019ISSN
1076-2752Publisher version
Language
- en