PA Telomere SABPA_JSMPF_accepted_22Mar2016.pdf (171.11 kB)

Association between objectively measured physical activity, chronic stress and leukocyte telomere length

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journal contribution
posted on 06.04.2016, 14:59 by Roland von Kaenel, Erna J. Bruwer, Mark Hamer, J. Hans de Ridder, Leone Malan
BACKGROUND: Physical activity (PA) attenuates chronic stress and age-related and cardiovascular disease risks, whereby potentially slowing telomere shortening. We aimed to study the association between seven-day objectively measured habitual PA, chronic stress and leukocyte telomere length. METHODS: Study participants were African (n=96) and Caucasian (n=107) school teachers of the Sympathetic activity and Ambulatory Blood Pressure in Africans study. All lifestyle characteristics (including PA) were objectively measured. The general health questionnaire and serum cortisol were assessed as psychological and physical measures of chronic stress. Leukocyte telomere length was measured using the quantitative real-time polymerase chain reaction. RESULTS: Africans had significantly shorter telomeres (p<.001) and greater psychological distress (p=0.001) than Caucasians, whereas no group difference was seen for cortisol levels. Higher age [ß=-0.28 (-0.40, -0.16), p≤0.000], higher alcohol consumption [ß=-0.21 (-0.36, -0.08), p=0.003] and increased central obesity [ß=-0.17 (-0.30, -0.03), p=0.017] were all significantly associated with shorter telomeres. Habitual PA of different intensity was not significantly associated with markers of chronic stress or telomere length. However, more time spent with light intensity PA time was significantly and independently correlated with lower waist circumference (r=-0.21, p=0.004); in turn, greater waist circumference was significantly associated shorter telomeres [β=-0.17 (-0.30, -0.03), p=0.017]. CONCLUSION: Habitual PA of different intensity was not directly associated with markers of chronic stress and leukocyte telomere length in this biethnic cohort. However, our findings suggest that light intensity PA could contribute to lowered age-related disease risk and healthy ageing by facilitating maintenance of a normal waist circumference.

Funding

The SABPA study is funded by the North-West University, the North-West Education Department, the Medical Research Council of South Africa, the National Research Foundation, Roche Diagnostics, South Africa and the Metabolic Syndrome Institute, France.

History

School

  • Sport, Exercise and Health Sciences

Published in

The Journal of Sports Medicine and Physical Fitness

Citation

VON KAENEL, R. ... et al, 2016. Association between objectively measured physical activity, chronic stress and leukocyte telomere length. The Journal of Sports Medicine and Physical Fitness, 57 (10), pp. 1349-1358.

Publisher

Minerva Medica (© Edizioni Minerva Medica)

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

22/03/2016

Publication date

2016

Notes

This paper was accepted for publication in the journal The Journal of Sports Medicine and Physical Fitness and the definitive published version is available at https://doi.org/10.23736/S0022-4707.16.06426-4.

ISSN

0022-4707

eISSN

1827-1928

Language

en

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