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Association of objectively measured physical activity with brain structure: UK Biobank study

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journal contribution
posted on 22.05.2018, 13:56 by Mark Hamer, Nikhil Sharma, G. David Batty
Background Physical activity may be beneficial for cognition but mechanisms are unclear. We examined the association between objectively assessed physical activity and brain volume, with a focus on the hippocampus region. Methods We used data from UK Biobank (n=5,272; aged 55.4±7.5 yrs; 45.6% men) collected through 2013‐2016. Participants wore the Axivity AX3 wrist‐worn triaxial accelerometer for seven days to assess habitual physical activity. Structural magnetic resonance imaging was performed using a standard Siemens Skyra 3T running VD13A SP4 to obtain images of the brain. Results There was an association between physical activity (per SD increase) and grey matter volume after adjustment for a range of covariates, although this association was only detected in older adults (>60 yrs old). We also observed associations of physical activity with both left (B=0.52, 95% CI, 0.01, 1.03; p=0.046) and right hippocampal volume (B=0.59, 95% CI, 0.08, 1.10; p=0.024) in covariate adjusted models. Conclusion In summary, physical activity may play a role in the prevention of neurodegenerative diseases.

Funding

This research has been conducted using the UK Biobank Resource under Application Number 23476. Hamer acknowledges support from the NIHR Leicester BRC.

History

School

  • Sport, Exercise and Health Sciences

Published in

Journal of Internal Medicine

Citation

HAMER, M., SHARMA, N. and BATTY, G.D., 2018. Association of objectively measured physical activity with brain structure: UK Biobank study. Journal of Internal Medicine, 284 (4), pp.439-443.

Publisher

Wiley © The Association for the Publication of the Journal of Internal Medicine

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

03/05/2018

Publication date

2018

Notes

This is the peer reviewed version of the following article: HAMER, M., SHARMA, N. and BATTY, G.D., 2018. Association of objectively measured physical activity with brain structure: UK Biobank study. Journal of Internal Medicine, 284 (4), pp.439-443, which has been published in final form at https://doi.org/10.1111/joim.12772. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

ISSN

0954-6820

eISSN

1365-2796

Language

en