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Associations of childhood BMI traits with blood pressure and glycated haemoglobin in 6–9-year-old Samoan children

journal contribution
posted on 2024-03-07, 16:20 authored by Courtney C. Choy, Will JohnsonWill Johnson, Joseph M. Braun, Christina Soti-Ulberg, Muagututia S. Reupena, Take Naseri, Kima Savusa, Vaimoana Filipo Lupematasila, Maria Siulepa Arorae, Faatali Tafunaina, Folla Unasa, Rachel L. Duckham, Dongqing Wang, Stephen T. McGarvey, Nicola L. Hawley

Introduction: Prevalence and risk factors for elevated glycated haemoglobin (HbA1c) and blood pressure (BP) are poorly understood among Pacific children. We examined associations of HbA1c and BP in 6–9 year-olds with body mass index (BMI) at ages 2, 5, and BMI velocity between 2–9 years in Samoa.

Methods: HbA1c (capillary blood) and BP were measured in n = 410 Samoan children who were part of an ongoing cohort study. Multilevel models predicted BMI trajectory characteristics. Generalized linear regressions assessed associations of childhood characteristics and BMI trajectories with HbA1c and BP treated as both continuous and categorical outcomes. Primary caregiver-reported childhood characteristics were used as covariates.

Results: Overall, 12.90% (n = 53) of children had high HbA1c (≥5.7%) and 33.17% (n = 136) had elevated BP. BMI at 5-years and BMI velocity were positively associated with high HbA1c prevalence in males. A 1 kg/m2 per year higher velocity was associated with a 1.71 (95% CI: 1.07, 2.75) times higher prevalence of high HbA1c. In females, higher BMI at 5-years and greater BMI velocity were associated with higher BP at 6–9 years (95% CI: 1.12, 1.40, and 1.42, 2.74, respectively).

Conclusion: Monitoring childhood BMI trajectories may inform cardiometabolic disease screening and prevention efforts in this at-risk population.

Funding

NIHR Leicester Biomedical Research Centre

Global Health Equity Scholars Program.

Fogarty International Center

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A multilevel and structural equation modeling approach to understand longitudinal growth, obesity, and cardiometabolic risk among Samoan children

National Heart Lung and Blood Institute

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National Institutes of Health. Grant Numbers: HL140570, K99HL166781, K99HL166781-01A1

Brown Population Studies and Training Center

Eunice Kennedy Shriver National Institute of Child Health and Human Development

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Integrated cellular, mouse and human research on a novel missense variant influencing adiposity in Samoans

National Heart Lung and Blood Institute

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Training in Demography

Eunice Kennedy Shriver National Institute of Child Health and Human Development

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Brown NIMHD Minority Health & Health Disparities International Research Training

National Institute on Minority Health and Health Disparities

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History

School

  • Sport, Exercise and Health Sciences

Published in

Pediatric Obesity

Publisher

Wiley

Version

  • AM (Accepted Manuscript)

Rights holder

© World Obesity Federation

Publisher statement

This is the peer reviewed version of the following article: Choy CC, Johnson W, Braun JM, et al. Associations of childhood BMI traits with blood pressure and glycated haemoglobin in 6–9-year-old Samoan children. Pediatric Obesity. 2024;e13112. doi:10.1111/ijpo.13112, which has been published in final form at https://doi.org/10.1111/ijpo.13112. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.

Acceptance date

2024-02-19

Publication date

2024-03-04

Copyright date

2024

eISSN

2047-6310

Language

  • en

Depositor

Dr Will Johnson. Deposit date: 21 February 2024

Article number

e13112

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