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Biogenic aldehyde determination by reactive paper spray ionization mass spectrometry

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journal contribution
posted on 24.02.2015, 16:04 by Soumabha Bag, P.I. Hendricks, Jim ReynoldsJim Reynolds, R.G. Cooks
Ionization of aliphatic and aromatic aldehydes is improved by performing simultaneous chemical derivatization using 4-aminophenol to produce charged iminium ions during paper spray ionization. Accelerated reactions occur in the microdroplets generated during the paper spray ionization event for the tested aldehydes (formaldehyde, n-pentanaldehyde, n-nonanaldehyde, n-decanaldehyde, n-dodecanaldehyde, benzaldehyde, m-anisaldehyde, and p-hydroxybenzaldehyde). Tandem mass spectrometric analysis of the iminium ions using collision-induced dissociation demonstrated that straight chain aldehydes give a characteristic fragment at m/. z 122 (shown to correspond to protonated 4-(methyleneamino)phenol), while the aromatic aldehyde iminium ions fragment to give a characteristic product ion at m/. z 120. These features allow straightforward identification of linear and aromatic aldehydes. Quantitative analysis of n-nonaldehyde using a benchtop mass spectrometer demonstrated a linear response over 3 orders of magnitude from 2.5. ng to 5. μg of aldehyde loaded on the filter paper emitter. The limit of detection was determined to be 2.2. ng for this aldehyde. The method had a precision of 22%, relative standard deviation. The experiment was also implemented using a portable ion trap mass spectrometer.

Funding

The authors acknowledge funding from the National Science Foundation CHE1307264.

History

School

  • Science

Department

  • Chemistry

Published in

Analytica Chimica Acta

Citation

BAG, S. ... et al, 2015. Biogenic aldehyde determination by reactive paper spray ionization mass spectrometry. Analytica Chimica Acta, 860, pp.37–42.

Publisher

© Elsevier

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2015

Notes

This is the author’s version of a work that was accepted for publication in Analytica Chimica Acta. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published at: http://dx.doi.org/10.1016/j.aca.2015.01.007

ISSN

0003-2670

eISSN

1873-4324

Other identifier

S0003-2670(15)00010-0

Language

en