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Bioinspired poly(vinylidene fluoride) membranes with directional release of therapeutic essential oils

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posted on 2018-10-08, 15:35 authored by G. Balzamo, Helen WillcockHelen Willcock, Junaid Ali, Elizabeth RatcliffeElizabeth Ratcliffe, Elisa MeleElisa Mele
Here, the morphology of polypore fungi has inspired the fabrication of poly(vinylidene fluoride) (PVDF) membranes with dual porosity by nonsolvent-induced phase separation (NIPS). The fruiting body of such microorganisms is constituted of two distinct regions, finger- and sponge-like structures, which have been successfully mimicked by controlling the coagulation bath temperature during the NIPS process. The use of water at 10 °C as coagulant resulted in membranes with the highest finger-like/sponge-like ratio (53% of the total membrane thickness), while water at 90 °C allowed the formation of macrovoid-free membranes. The microchannels and the asymmetric porosity were used to enhance the oil sorption capacity of the PVDF membranes and to achieve directional release of therapeutic essential oils. These PVDF membranes with easily tuned asymmetric channel-like porosity and controlled pore size are ideal candidates for drug delivery applications.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Materials

Published in

Langmuir

Volume

34

Issue

29

Pages

8652-8660

Citation

BALZAMO, G. ... et al, 2018. Bioinspired poly(vinylidene fluoride) membranes with directional release of therapeutic essential oils. Langmuir, 34 (29), pp.8652–8660.

Publisher

© American Chemical Society

Version

  • AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2018-06-29

Copyright date

2018

Notes

This document is the Accepted Manuscript version of a Published Work that appeared in final form in Langmuir copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.langmuir.8b01175

ISSN

0743-7463

eISSN

1520-5827

Language

  • en

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