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CT-based airway flow model to assess ventilation in chronic obstructive pulmonary disease: a pilot study

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journal contribution
posted on 29.10.2019, 12:15 by Minsuok KimMinsuok Kim, Ozkan Doganay, Tahreema N Matin, Thomas Povey, Fergus V Gleeson
Background The lack of functional information in thoracic CT remains a limitation of its use in the clinical management of chronic obstructive pulmonary disease (COPD). Purpose To compare the distribution of pulmonary ventilation assessed by a CT-based full-scale airway network (FAN) flow model with hyperpolarized xenon 129 (129Xe) MRI (hereafter, 129Xe MRI) and technetium 99m-diethylenetriaminepentaacetic acid aerosol SPECT ventilation imaging (hereafter, V-SPECT) in participants with COPD. Materials and Methods In this prospective study performed between May and August 2017, pulmonary ventilation in participants with COPD was computed by using the FAN flow model. The modeled pulmonary ventilation was compared with functional imaging data from breath-hold time-series 129Xe MRI and V-SPECT. FAN-derived ventilation images on the coronal plane and volumes of interest were compared with functional lung images. Percentage lobar ventilation estimated by the FAN model was compared with that measured at 129Xe MRI and V-SPECT. The statistical significance of ventilation distribution between FAN and functional images was demonstrated with the Spearman correlation coefficient and χ2 distance. Results For this study, nine participants (seven men [mean age, 65 years ± 5 {standard deviation}] and two women [mean age, 63 years ± 7]) with COPD that was Global Initiative for Chronic Obstructive Lung Disease stage II-IV were enrolled. FAN-modeled ventilation profile showed strong positive correlation with images from 129Xe MRI (ρ = 0.67; P < .001) and V-SPECT (ρ = 0.65; P < .001). The χ2 distances of the ventilation histograms in the volumes of interest between the FAN and 129Xe MRI and FAN and V-SPECT were 0.16 ± 0.08 and 0.28 ± 0.14, respectively. The ratios of lobar ventilations in the models were linearly correlated to images from 129Xe MRI (ρ = 0.67; P < .001) and V-SPECT (ρ = 0.59; P < .001). Conclusion A CT-based full-scale airway network flow model provided regional pulmonary ventilation information for chronic obstructive pulmonary disease and correlates with hyperpolarized xenon 129 MRI and technetium 99m-diethylenetriaminepentaacetic acid aerosol SPECT ventilation imaging.

Funding

Cancer Research UK (C5255)

Engineering and Physical Sciences Research Council in the UK (A16466)

NIHR Biomedical Research Centre, Oxford

History

School

  • Mechanical, Electrical and Manufacturing Engineering

Published in

Radiology

Volume

293

Issue

3

Pages

666 - 673

Publisher

Radiological Society of North America (RSNA)

Version

VoR (Version of Record)

Rights holder

© RSNA

Acceptance date

22/08/2019

Publication date

2019-10-15

Copyright date

2019

ISSN

0033-8419

eISSN

1527-1315

Language

en

Depositor

Dr Minsuok Kim. Deposit date: 28 October 2019

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