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Scandinavian Med Sci Sports - 2023 - Craig - Calf blood flow is augmented in habitually aerobically trained versus.pdf (234.38 kB)

Calf blood flow is augmented in habitually aerobically trained versus untrained postmenopausal women in association with favorable modulation of vasculo‐metabolic interactions

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posted on 2023-05-16, 11:30 authored by Jen Craig, Liz AkamLiz Akam, Stephen BaileyStephen Bailey, Richard FergusonRichard Ferguson, Emma ODonnellEmma ODonnell

Introduction: Menopause is associated with vascular dysfunction and increased risk of developing metabolic syndrome. Associations between vascular and metabolic health, and interactions with aerobic exercise training, are unknown in postmenopausal women (PMW).

Methods: In habitually aerobically trained PMW (PMWtr; n = 10; 57 ± 1 years; 40 ± 1 mL/kg/min), strain-gauge plethysmography was used to compare resting and peak calf blood flow (CBFr and CBFpk, respectively) and vascular resistance (CVRr; CVRpk) versus untrained PMW (PMWun; n = 13; 56 ± 1 years; 29 ± 1 mL/kg/min) and premenopausal women (PreM; n = 14; 26 ± 1 years; 40 ± 1 mL/kg/min). Vascular measures were taken before and 1 hour after 45 minutes of aerobic exercise (60% V̇O2peak), a known nitric oxide stimulus. Blood analyses included low- (LDLc) and high-density lipoprotein cholesterol (HDLc), insulin, and glucose.

Results: Pre-exercise, CBFr and CVRr did not differ (p > 0.05) between PMW groups, nor between PreM and PMWtr. CBFpk was highest (p < 0.05) and CVRpk was lowest (p < 0.05) in PMWtr. Blood markers were similar (p > 0.05) in PMW groups. However, in PMWtr, CBFpk was associated inversely (p < 0.05) with insulin (r = −0.725). Conversely, in PMWun, CBFpk correlated (p < 0.05) inversely with glucose (r = −0.717), positively with HDLc (r = 0.633), and CVRpk positively (p < 0.05) with LDLc (r = 0.568). Post-exercise, CBF increased and CVR decreased (p < 0.05) in all groups, yet CBFpk remained higher and CVRpk lower (p < 0.05) in PMWtr.

Conclusion: In untrained PMW, peak CBF is associated inversely with circulating pro-atherogenic lipids and glucose. In contrast, peak CBF is associated inversely with insulin levels only in trained PMW. Habitual aerobic exercise may favorably modulate vasculo-metabolic interactions in PMW.

Funding

National Institute for Health Research (NIHR) Leicester Biomedical Research Centre

History

School

  • Sport, Exercise and Health Sciences

Published in

Scandinavian Journal of Medicine & Science in Sports

Volume

33

Issue

6

Pages

882-893

Publisher

Wiley

Version

  • VoR (Version of Record)

Rights holder

© The Authors

Publisher statement

This is an Open Access Article. It is published by Wiley under the Creative Commons Attribution 4.0 International Licence (CC BY). Full details of this licence are available at: https://creativecommons.org/licenses/by/4.0/

Acceptance date

2023-02-01

Publication date

2023-02-24

Copyright date

2023

ISSN

0905-7188

eISSN

1600-0838

Language

  • en

Depositor

Dr Emma O'Donnell. Deposit date: 13 March 2023

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