Morris, 2020 - Cancer-Associated Fibroblasts in Undifferentiated Nasopharyngeal Carcinoma- A Putative Role for the EBV-Encoded Oncoprotein, LMP1.pdf (364.8 kB)
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Cancer-associated fibroblasts in undifferentiated nasopharyngeal carcinoma: a putative role for the EBV-encoded oncoprotein, LMP1

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journal contribution
posted on 03.03.2020, 09:27 by Mhairi MorrisMhairi Morris
Undifferentiated nasopharyngeal carcinoma (NPC) is 100% associated with Epstein–Barr virus (EBV) infection, and biopsies display variable levels of expression of the viral oncoprotein, latent membrane protein 1 (LMP1). Emerging evidence suggests an important role for cancer-associated fibroblasts (CAFs) in the NPC tumour microenvironment, yet the interaction between the virus, its latent gene products and the recruitment and activation of CAFs in the NPC tumour stroma remains unclear. This short review will discuss the current evidence for the importance of CAFs in NPC pathogenesis and outline a putative role for the EBV-encoded oncoprotein, LMP1, in governing tumour–stromal interactions.

History

School

  • Sport, Exercise and Health Sciences

Published in

Pathogens

Volume

9

Issue

1

Publisher

MDPI AG

Version

VoR (Version of Record)

Rights holder

© The author

Publisher statement

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

Acceptance date

18/12/2019

Publication date

2019-12-20

Copyright date

2019

ISSN

2076-0817

eISSN

2076-0817

Language

en

Depositor

Dr Mhairi Morris. Deposit date: 2 March 2020

Article number

8