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Cardiovascular disease risk marker responses to breaking up prolonged sedentary time in individuals with paraplegia: the Spinal Cord Injury Move More (SCIMM) randomised crossover laboratory trial protocol
journal contribution
posted on 2018-06-12, 13:12 authored by Thomas M. Withers, Louise Croft, Vicky Goosey-TolfreyVicky Goosey-Tolfrey, David W. Dunstan, Christof LeichtChristof Leicht, Daniel P. BaileyIntroduction: Sedentary behaviour is a distinct risk factor for cardiovascular disease (CVD) and could partly explain the increased prevalence of CVD in people with spinal cord injury (SCI). Interrupting prolonged sitting periods with regular short bouts of walking acutely suppresses postprandial glucose and lipids in able-bodied individuals. However, the acute CVD risk marker response to breaking up prolonged sedentary time in people with SCI has not been investigated. Methods and analysis: A randomised two-condition laboratory crossover trial will compare: 1) breaking up prolonged sedentary time with 2 min moderate-intensity arm crank activity every 20 min, with 2) uninterrupted prolonged sedentary time (control) in people with SCI. Outcomes will include acute effects on postprandial glucose, insulin, lipids and blood pressure. Blood samples will be collected and blood pressure measured at regular intervals during each 5.5 h condition. Ethics and dissemination: This study was approved by the Cambridge South NHS Research Ethics Committee. This research will help determine if breaking up prolonged sedentary time could be effective in lowering CVD risk in people with SCI. The findings of the research will be published in a peer review journal and disseminated to relevant user groups. Trial registration: The study is registered as a clinical trial on the ISRCTN register (trial ID: ISRCTN51868437).
Funding
This work is supported by Heart Research UK grant number RG2655/17/18.
History
School
- Sport, Exercise and Health Sciences
Published in
BMJ OpenCitation
WITHERS, T.M. ... et al, 2018. Cardiovascular disease risk marker responses to breaking up prolonged sedentary time in individuals with paraplegia: the Spinal Cord Injury Move More (SCIMM) randomised crossover laboratory trial protocol. BMJ Open, 8, e021936.Publisher
BMJ Publishing Group © The AuthorsVersion
- NA (Not Applicable or Unknown)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/by-nc/4.0/Acceptance date
2018-05-24Publication date
2018-06-22Notes
This is an Open Access Article. It is published by BMJ under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/by-nc/4.0/eISSN
2044-6055Publisher version
Language
- en