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Cellular therapy using microglial cells
journal contributionposted on 2015-02-26, 16:21 authored by John Schloendorn, Sebastian Sethe, Alexandra StolzingAlexandra Stolzing
Recent insights into the function and dysfunction of microglia may inform future therapies to combat neurodegeneration. We hypothesise how different aspects of microglial activity including migration, activation, oxidative response, phagocytosis, proteolysis, and replenishment could be targeted by novel therapeutic approaches. A combined approach is suggested, encompassing opsonization and anti-inflamatory strategies in conjunction with an engineering of microglial precursors. Xenoproteases for bioremediation could be used to enhance intracellular and extracellular proteolytic capacity. The capacity of microglial precursors to cross the blood-brain barrier and to home in on sites of neural damage and inflammation might prove to be particularly useful for future therapeutic strategies. © Mary Ann Liebert, Inc.
- Mechanical, Electrical and Manufacturing Engineering
Published inRejuvenation Research
Pages87 - 99
CitationSCHLOENDORN, J., SETHE, S. and STOLZING, A., 2007. Cellular therapy using microglial cells. Rejuvenation Research, 10 (1), pp. 87 - 99.
Publisher© Mary Ann Liebert, Inc.
- VoR (Version of Record)
Publisher statementThis work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/
NotesThis article is closed access.