File(s) under permanent embargo

Reason: This item is currently closed access.

Cellular therapy using microglial cells

journal contribution
posted on 26.02.2015, 16:21 authored by John Schloendorn, Sebastian Sethe, Alexandra StolzingAlexandra Stolzing
Recent insights into the function and dysfunction of microglia may inform future therapies to combat neurodegeneration. We hypothesise how different aspects of microglial activity including migration, activation, oxidative response, phagocytosis, proteolysis, and replenishment could be targeted by novel therapeutic approaches. A combined approach is suggested, encompassing opsonization and anti-inflamatory strategies in conjunction with an engineering of microglial precursors. Xenoproteases for bioremediation could be used to enhance intracellular and extracellular proteolytic capacity. The capacity of microglial precursors to cross the blood-brain barrier and to home in on sites of neural damage and inflammation might prove to be particularly useful for future therapeutic strategies. © Mary Ann Liebert, Inc.

History

School

  • Mechanical, Electrical and Manufacturing Engineering

Published in

Rejuvenation Research

Volume

10

Issue

1

Pages

87 - 99

Citation

SCHLOENDORN, J., SETHE, S. and STOLZING, A., 2007. Cellular therapy using microglial cells. Rejuvenation Research, 10 (1), pp. 87 - 99.

Publisher

© Mary Ann Liebert, Inc.

Version

VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2007

Notes

This article is closed access.

ISSN

1549-1684

Language

en

Usage metrics

Keywords

Exports