VO2peak SR 21.03.2019.pdf (610.53 kB)
Change in V˙O2peak in response to aerobic exercise training and the relationship with exercise prescription in people with COPD: a systematic review and meta-analysis
journal contribution
posted on 2020-06-23, 12:36 authored by Thomas Ward, Charles D Plumptre, Thomas E Dolmage, Amy Jones, Ruth Trethewey, Pip Divall, Sally Singh, Martin Lindley, Michael C Steiner, Rachael EvansBACKGROUND: ▪▪▪ RESEARCH QUESTION: The goal of this study was to investigate the effect of aerobic training and exercise prescription on peak oxygen uptake (V˙O2peak) in COPD. STUDY DESIGN AND METHODS: A systematic review was performed by using MEDLINE, Embase, Cumulative Index to Nursing and Allied Health Literature, and Cochrane databases for all studies measuring V˙O2peak prior to and following supervised lower-limb aerobic training in COPD. A random effects meta-analysis limited to randomized controlled trials comparing aerobic training vs usual care was conducted. Other study designs were included in a secondary meta-analysis and meta-regression to investigate the influence of program and patient factors on outcome. RESULTS: A total of 112 studies were included (participants, N = 3,484): 21 controlled trials (n = 489), of which 13 were randomized (n = 288) and 91 were uncontrolled (n = 2,995) studies. Meta-analysis found a moderate positive change in V˙O2peak (standardized mean difference, 0.52; 95% CI, 0.34-0.69) with the intervention. The change in V˙O2peak was positively associated with target duration of exercise session (P = .01) and, when studies > 1 year duration were excluded, greater total volume of exercise training (P = .01). Similarly, the change in V˙O2peak was greater for programs > 12 weeks compared with those 6 to 12 weeks when adjusted for age and sex. However, reported prescribed exercise intensity (P = .77), training modality (P > .35), and mode (P = .29) did not affect V˙O2peak. Cohorts with more severe airflow obstruction exhibited smaller improvements in V˙O2peak (P < .001). INTERPRETATION: Overall, people with COPD achieved moderate improvements in V˙O2peak through supervised aerobic training. There is sufficient evidence to show that programs with greater total exercise volume, including duration of exercise session and program duration, are more effective. Reduced effects in severe disease suggest alternative aerobic training methods may be needed in this population. CLINICAL TRIAL REGISTRATION: PROSPERO; No.: CRD42018099300; URL: www.clinicaltrials.gov.
History
School
- Sport, Exercise and Health Sciences
Published in
ChestVolume
158Issue
1Pages
131 - 144Publisher
ElsevierVersion
- AM (Accepted Manuscript)
Rights holder
© American College of Chest PhysiciansPublisher statement
This paper was accepted for publication in the journal Chest and the definitive published version is available at https://doi.org/10.1016/j.chest.2020.01.053.Acceptance date
2020-01-06Publication date
2020-03-12Copyright date
2020ISSN
0012-3692eISSN
1931-3543Publisher version
Language
- en
Depositor
Dr Martin Lindley. Deposit date: 22 June 2020Usage metrics
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