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Characterization of biodegradable poly(l‐lactide) tube over accelerated degradation

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journal contribution
posted on 30.03.2020, 08:10 by Raasti Naseem, Liguo ZhaoLiguo Zhao, Senthil K. Eswaran, Helen WillcockHelen Willcock
The next‐generation bioresorbable polymeric stents are undergoing continual research and development, especially how to control and optimize their degradation behaviors. The aim of this paper is to study the properties of a poly(l‐lactide) (PLLA) tube over accelerated degradation in vitro. Spherical nanoindentation was particularly adopted to measure the mechanical properties of PLLA tube; while differential scanning calorimetry and gel permeation chromatography were used for crystallinity and molecular weight measurements. Overall, the material degradation was captured by the local stress‐strain response obtained with spherical nanoindentation, and further confirmed with chemical analyses. The results are particularly useful for development of bioresorbable polymeric stents with improved performance.

Funding

British Heart Foundation (Grant reference: FS/15/21/31424; Title: Towards controlling the mechanical performance of polymeric bioresorbable vascular stent during biodegradation)

History

School

  • Mechanical, Electrical and Manufacturing Engineering
  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Materials

Published in

Polymer Engineering and Science

Volume

60

Issue

7

Pages

1430 - 1436

Publisher

Wiley Periodicals, Inc. on behalf of Society of Plastics Engineers

Version

VoR (Version of Record)

Rights holder

© The Authors

Publisher statement

This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Acceptance date

27/03/2020

Publication date

2020-04-08

Copyright date

2020

ISSN

0032-3888

eISSN

1548-2634

Language

en

Depositor

Prof Liguo Zhao. Deposit date: 27 March 2020