Chiral counterion strategy in Cu-catalyzed asymmetric allylic oxidation of linear alkenes
journal contributionposted on 23.05.2016, 10:10 by Celia A. Incerti-Pradillos, Daniel Hudson, Andrei MalkovAndrei Malkov
Application of a chiral counter-ion strategy in the Kharasch-Sosnovsky reaction is reported. Copper(I) phosphates obtained from axially chiral, BINOL-derived phosphoric acids were investigated as catalysts in the enantioselective allylic oxidation of acyclic alkenes. Good yields and high regioselectivity towards branched allylic ester have been achieved. The chiral phosphates investigated exhibited modest enantioselectivities.