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Chitosan and Poly (Vinyl Alcohol) microparticles produced by membrane emulsification for encapsulation and pH controlled release

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journal contribution
posted on 08.03.2016, 09:58 by Serena Morelli, Richard Holdich, Marijana DragosavacMarijana Dragosavac
© 2015 Elsevier B.V. The Dispersion Cell membrane emulsification technique was used for the production of w/o emulsions with controlled droplet size and narrow size distribution. The influence of the operating parameters of the process was investigated. Varying the dispersed phase flux (10-1250 L h-1 m-2) and the shear stress (2-59 Pa), droplets between 30 and 280 μm were produced with CV's as low as 18%. Nickel and stainless steel membranes were used for the membrane emulsification. Pore geometry influenced the droplet size as well as uniformity and a normally hydrophilic stainless steel membrane with sharp pore openings produced more uniform and smaller drops compared to a PTFE coated hydrophobic nickel membrane with a conical pore surface. For the dispersed phase 15 wt.% PVA or 1-3 wt.% chitosan as well as their blends in water were used. Surfactants PGPR and ABIL EM90 were tested to determine their capability to form stable emulsions in Miglyol 840. PGPR could not be used to stabilize the emulsion with chitosan as the dispersed phase, probably due to the chemical interference between the carboxyl group present in the PGPR and chitosan. Solid microparticles were obtained by chemical crosslinking with glutaraldehyde (GA) at different concentrations (1-50 vol.%). Particles crosslinked using less than 10 vol.% GA were able to swell and release encapsulated compounds. Acid sensitive particles were produced by blending the PVA and chitosan. Up to 80% of Cu2+ and 20% of sodium salicylate was released from the particles under acidic conditions. No significant release was determined under neutral conditions.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Published in

Chemical Engineering Journal

Volume

288

Pages

451 - 460

Citation

MORELLI, S., HOLDICH, R.G. and DRAGOSAVAC, M.M., 2016. Chitosan and Poly (Vinyl Alcohol) microparticles produced by membrane emulsification for encapsulation and pH controlled release. Chemical Engineering Journal, 288, pp. 451-460.

Publisher

© Elsevier

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2015-12-17

Notes

This paper was accepted for publication in the journal Chemical Engineering Journal and the definitive published version is available at http://dx.doi.org/10.1016/j.cej.2015.12.024

ISSN

1385-8947

Language

en