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Chronic inflammation as a determinant of future aging phenotypes

journal contribution
posted on 02.11.2015, 10:56 authored by Tasnime N. Akbaraly, Mark Hamer, Jane E. Ferrie, Gordon Lowe, G. David Batty, Gareth Hagger-Johnson, Archana Singh-Manoux, Martin J. Shipley, Mika Kivimaki
Background: The importance of chronic inflammation as a determinant of aging phenotypes may have been underestimated in previous studies that used a single measurement of inflammatory markers. We assessed inflammatory markers twice over a 5-year exposure period to examine the association between chronic inflammation and future aging phenotypes in a large population of men and women. Methods: We obtained data for 3044 middle aged adults (28.2% women) who were participating in the Whitehall II study and had no history of stroke, myocardial infarction or cancer at our study’s baseline (1997–1999). Interleukin-6 was measured at baseline and 5 years earlier. Cause-specific mortality, chronic disease and functioning were ascertained from hospital data, register linkage and clinical examinations. We used these data to create 4 aging phenotypes at the 10-year follow-up (2007–2009): successful aging (free of major chronic disease and with optimal physical, mental and cognitive functioning), incident fatal or nonfatal cardiovascular disease, death from noncardiovascular causes and normal aging (all other participants). Results: Of the 3044 participants, 721 (23.7%) met the criteria for successful aging at the 10-year follow-up, 321 (10.6%) had cardiovascular disease events, 147 (4.8%) died from noncardiovascular causes, and the remaining 1855 (60.9%) were included in the normal aging phenotype. After adjustment for potential confounders, having a high interleukin-6 level (> 2.0 ng/L) twice over the 5-year exposure period nearly halved the odds of successful aging at the 10-year follow-up (odds ratio [OR] 0.53, 95% confidence interval [CI] 0.38–0.74) and increased the risk of future cardiovascular events (OR 1.64, 95% CI 1.15–2.33) and noncardiovascular death (OR 2.43, 95% CI 1.58–3.80). Interpretation: Chronic inflammation, as ascertained by repeat measurements, was associated with a range of unhealthy aging phenotypes and a decreased likelihood of successful aging. Our results suggest that assessing long term chronic inflammation by repeat measurement of interleukin-6 has the potential to guide clinical practice.

Funding

The Whitehall II study is supported by grants from the British Medical Research Council (MRC grant no. K013351), the British Heart Foundation, the British Health and Safety Executive, the British Department of Health, the US National Heart, Lung, and Blood Institute (grant no. R01HL036310), the US National Institute on Aging (grant nos. R01AG013196 and R01AG034454) and the US Agency for Health Care Policy and Research (grant no. HS06516).

History

School

  • Sport, Exercise and Health Sciences

Published in

Canadian Medical Association journal

Citation

AKBARALY, T.N. ... et al., 2013. Chronic inflammation as a determinant of future aging phenotypes. Canadian Medical Association Journal, 185(16), pp. E763-E770.

Publisher

© Canadian Medical Association

Version

VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2013

Notes

This paper is in closed access.

ISSN

0008-4409

Language

en

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