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Circulating endotoxin and inflammation: associations with fitness, physical activity and the effect of a six-month programme of cycling exercise during haemodialysis

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posted on 17.05.2021, 10:35 by Daniel S March, Ka-Bik Lai, Tracy Neal, Matthew PM Graham-Brown, Patrick J Highton, Darren R Churchward, Hannah ML Young, Maurice Dungey, David StenselDavid Stensel, Alice C Smith, Nicolette BishopNicolette Bishop, Cheuk Chun Szeto, James Burton
Background: Intradialytic cycling (IDC) may provide cardiovascular benefit to individuals receiving haemodialysis, but the exact mechanism behind these improvements remains unclear. The primary aim of this study was to investigate the effect of a six-month programme of IDC on circulating endotoxin (secondary analysis from the CYCLE-HD trial). Secondary aims were to investigate changes in circulating cytokines (IL-6, IL-10, TNF-α, CRP and IL6/IL-10), and their associations with physical activity, fitness and cardiovascular outcomes.
Methods: Participants were randomised to either a six-month programme of IDC (thrice weekly, moderate intensity cycling at RPE 12-14) in addition to usual care (n=46), or usual care only (control group; n=46). Outcome measures were obtained at baseline and then again at six months.
Results: There was no significant (P=0.137) difference in circulating endotoxin between groups at 6-months (IDC group: 0.34±0.08 EU/mL; control group: 0.37±0.07 EU/mL). There were no significant between group difference in any circulating cytokine following the 6-month programme of IDC. Higher levels of physical activity and fitness were associated with lower levels of endotoxin, IL-6, CRP, and IL-6/IL-10.
Conclusions: Our data show no change in circulating endotoxin or cytokines following a 6-month programme of IDC. However, higher levels of physical activity outside of haemodialysis were associated with lower levels of inflammation.

Funding

National Institute of Health 422 Research (NIHR) in the United Kingdom (Grant Reference Number CS-2013-13-014)

Leicester Kidney Care Appeal

History

School

  • Sport, Exercise and Health Sciences

Published in

Nephrology Dialysis Transplantation

Volume

37

Issue

2

Pages

366-374

Publisher

Oxford University Press

Version

AM (Accepted Manuscript)

Rights holder

© The Authors

Publisher statement

This is a pre-copyedited, author-produced version of an article accepted for publication in Nephrology Dialysis Transplantation following peer review. The version of record Daniel S March, Ka-Bik Lai, Tracy Neal, Matthew P M Graham-Brown, Patrick J Highton, Darren R Churchward, Hannah M L Young, Maurice Dungey, David J Stensel, Alice C Smith, Nicolette C Bishop, Cheuk Chun Szeto, James O Burton, Circulating endotoxin and inflammation: associations with fitness, physical activity and the effect of a six-month programme of cycling exercise during haemodialysis, Nephrology Dialysis Transplantation, 2021;, gfab178, https://doi.org/10.1093/ndt/gfab178 is available online at: https://doi.org/10.1093/ndt/gfab178.

Acceptance date

04/05/2021

Publication date

2021-05-13

Copyright date

2022

ISSN

0931-0509

eISSN

1460-2385

Language

en

Depositor

Prof David Stensel. Deposit date: 7 May 2021