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Download fileComparing the dynamic flow properties and compaction properties of pharmaceutical powder mixtures
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posted on 2017-09-22, 10:49 authored by Mark LeaperMark Leaper, Kashaf Ali, Andrew J. InghamThe dynamic flow properties and compaction characteristics of mannitol and
mannitol-sodium carbonate mixtures (80/20, 70/30 and 60/40 by mass) were measured
using a Freeman FT4 powder rheometer. The results showed that the mixtures containing
up to 30% sodium carbonate had better flow properties and improved compaction
characteristics when compared with mannitol alone. The study demonstrated the feasibility
of combining a more expensive pharmaceutical excipient with a cheaper ingredient, without
compromising desired powder characteristics. It may also provide a useful method for
assessing the suitability of new formulations for use as direct compression bases, as part of
a wider range of powder flow tests.
History
School
- Aeronautical, Automotive, Chemical and Materials Engineering
Department
- Chemical Engineering
Published in
Chemical Engineering and TechnologyCitation
LEAPER, M.C., ALI, K. and INGHAM, A.J., 2018. Comparing the dynamic flow properties and compaction properties of pharmaceutical powder mixtures. Chemical Engineering and Technology, 41(1), pp. 102-107.Publisher
© WileyVersion
- AM (Accepted Manuscript)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Acceptance date
2017-09-19Publication date
2018Notes
This is the pre-peer reviewed version of the following article: LEAPER, M.C., ALI, K. and INGHAM, A.J., 2018. Comparing the dynamic flow properties and compaction properties of pharmaceutical powder mixtures. Chemical Engineering and Technology, 41(1), pp. 102-107., which has been published in final form at https://doi.org/10.1002/ceat.201600651. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived VersionsISSN
0930-7516eISSN
1521-4125Publisher version
Language
- en