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Download fileComparing the dynamic flow properties and compaction properties of pharmaceutical powder mixtures
journal contribution
posted on 2017-09-22, 10:49 authored by Mark LeaperMark Leaper, Kashaf Ali, Andrew J. InghamThe dynamic flow properties and compaction characteristics of mannitol and
mannitol-sodium carbonate mixtures (80/20, 70/30 and 60/40 by mass) were measured
using a Freeman FT4 powder rheometer. The results showed that the mixtures containing
up to 30% sodium carbonate had better flow properties and improved compaction
characteristics when compared with mannitol alone. The study demonstrated the feasibility
of combining a more expensive pharmaceutical excipient with a cheaper ingredient, without
compromising desired powder characteristics. It may also provide a useful method for
assessing the suitability of new formulations for use as direct compression bases, as part of
a wider range of powder flow tests.
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