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Comparing the dynamic flow properties and compaction properties of pharmaceutical powder mixtures

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journal contribution
posted on 22.09.2017, 10:49 by Mark Leaper, Kashaf Ali, Andrew J. Ingham
The dynamic flow properties and compaction characteristics of mannitol and mannitol-sodium carbonate mixtures (80/20, 70/30 and 60/40 by mass) were measured using a Freeman FT4 powder rheometer. The results showed that the mixtures containing up to 30% sodium carbonate had better flow properties and improved compaction characteristics when compared with mannitol alone. The study demonstrated the feasibility of combining a more expensive pharmaceutical excipient with a cheaper ingredient, without compromising desired powder characteristics. It may also provide a useful method for assessing the suitability of new formulations for use as direct compression bases, as part of a wider range of powder flow tests.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Published in

Chemical Engineering and Technology

Citation

LEAPER, M.C., ALI, K. and INGHAM, A.J., 2018. Comparing the dynamic flow properties and compaction properties of pharmaceutical powder mixtures. Chemical Engineering and Technology, 41(1), pp. 102-107.

Publisher

© Wiley

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

19/09/2017

Publication date

2018

Notes

This is the pre-peer reviewed version of the following article: LEAPER, M.C., ALI, K. and INGHAM, A.J., 2018. Comparing the dynamic flow properties and compaction properties of pharmaceutical powder mixtures. Chemical Engineering and Technology, 41(1), pp. 102-107., which has been published in final form at https://doi.org/10.1002/ceat.201600651. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions

ISSN

0930-7516

eISSN

1521-4125

Language

en

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Keywords

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