Comparing the dynamic flow properties and compaction properties of pharmaceutical powder mixtures
journal contributionposted on 2017-09-22, 10:49 authored by Mark LeaperMark Leaper, Kashaf Ali, Andrew J. Ingham
The dynamic flow properties and compaction characteristics of mannitol and mannitol-sodium carbonate mixtures (80/20, 70/30 and 60/40 by mass) were measured using a Freeman FT4 powder rheometer. The results showed that the mixtures containing up to 30% sodium carbonate had better flow properties and improved compaction characteristics when compared with mannitol alone. The study demonstrated the feasibility of combining a more expensive pharmaceutical excipient with a cheaper ingredient, without compromising desired powder characteristics. It may also provide a useful method for assessing the suitability of new formulations for use as direct compression bases, as part of a wider range of powder flow tests.
- Aeronautical, Automotive, Chemical and Materials Engineering
- Chemical Engineering
Published inChemical Engineering and Technology
CitationLEAPER, M.C., ALI, K. and INGHAM, A.J., 2018. Comparing the dynamic flow properties and compaction properties of pharmaceutical powder mixtures. Chemical Engineering and Technology, 41(1), pp. 102-107.
- AM (Accepted Manuscript)
Publisher statementThis work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/
NotesThis is the pre-peer reviewed version of the following article: LEAPER, M.C., ALI, K. and INGHAM, A.J., 2018. Comparing the dynamic flow properties and compaction properties of pharmaceutical powder mixtures. Chemical Engineering and Technology, 41(1), pp. 102-107., which has been published in final form at https://doi.org/10.1002/ceat.201600651. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions