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Comparison of metabolomic profiles obtained using chemical ionization and electron ionization mass spectrometry in exhaled breath

journal contribution
posted on 17.01.2012, 12:11 by Matthew TurnerMatthew Turner, C. Guallar-Hoyas, A.L. Kent, Ian D. Wilson, Paul Thomas
The exhaled breath is rich in a wide range of volatile organic compounds with the potential to provide readily accessible biomarkers for metabolic activity in the body as a result of normal or abnormal/disease processes. Exhaled breath samples from five healthy volunteers have been analyzed by thermal desorption GC–MS using electron impact and chemical ionization. A total of eight compounds: 2-propenoic acid; 2-methyl, methyl ester; toluene; hexanal; 1,4-cyclohexadiene, 1-methyl-4-(1methlethyl); phenol; nonanal; dodecane and indole, have been evaluated to establish differences in selectivity and sensitivity using these two mechanisms of ionization. The combination of both electron impact and chemical ionization profiles could prove valuable when prospecting for breath-derived biomarkers as they result in complementary information that aids the identification of unknown components.

History

School

  • Science

Department

  • Chemistry

Citation

TURNER, M.A. ... et al., 2011. Comparison of metabolomic profiles obtained using chemical ionization and electron ionization MS in exhaled breath. Bioanalysis, 3 (24), pp. 2731-2738.

Publisher

© Future Science Group

Version

NA (Not Applicable or Unknown)

Publication date

2011

Notes

Closed access. This article was published in the journal, Bioanalysis [© Future Science Group] and the definitive version is available at: http://dx.doi.org/10.4155/bio.11.284

ISSN

1757-6180

Language

en

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