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Comparison of sleep structure and psychometric profiles in patients with fibromyalgia, osteoarthritis and healthy controls

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posted on 05.04.2018, 13:09 by Wai Yeung, Kevin Morgan, Frank McKenna
© 2017 European Sleep Research Society While research indicates that both the macro- and microstructure of sleep may be altered in fibromyalgia syndrome, few studies have controlled for symptom duration or included pain-control participants (i.e. patients with chronic pain and sleep disturbance not associated with fibromyalgia syndrome). A frequently reported alteration found in the sleep microstructure of patients with fibromyalgia syndrome is the alpha-delta sleep anomaly. Although alpha waves have been observed during N3 sleep in healthy individuals, it has been proposed that there is an increase in alpha wave activity during slow-wave sleep in fibromyalgia syndrome. Originally considered a possible neurological contribution to fibromyalgia syndrome, whether the alpha-delta sleep anomaly is fundamental to the development of fibromyalgia syndrome, or results mainly from the pain experience remains unknown. The present study was designed to compare sleep macro- and microstructure, and psychometric profiles, in three broadly age-matched groups of female participants: patients with fibromyalgia syndrome (n = 19); patients with osteoar thritis with sleep disturbance (n = 17); and healthy adults (n = 10). Patients with fibromyalgia syndrome met the American College of Rheumatology diagnostic criteria and were recruited within 6 months of diagnosis. Subjective sleep quality was significantly lowest, and levels of anxiety and depressive symptoms were significantly highest for patients with fibromyalgia syndrome. However, the groups showed no significant differences in polysomnographic measures of total sleep time, sleep latency and total wake after sleep onset. Levels of alpha-delta sleep were statistically similar in both clinical (fibromyalgia syndrome and osteoarthritis) groups, indicating that it is not a specific abnormality of fibromyalgia syndrome. Overall, subjective measurements of anxiety, depression, fatigue and sleep quality better discriminated between the three groups than did objective measurements of sleep variables.

Funding

This research was supported by Trafford General Hospital, Central Manchester University Hospital NHS Foundation Trust, and Loughborough University.

History

School

  • Sport, Exercise and Health Sciences

Published in

Journal of Sleep Research

Volume

27

Issue

2

Pages

290 - 298

Citation

YEUNG, W., MORGAN, K. and MCKENNA, F., 2018. Comparison of sleep structure and psychometric profiles in patients with fibromyalgia, osteoarthritis and healthy controls. Journal of Sleep Research, 27(2), pp. 290-298.

Publisher

© 2017 European Sleep Research Society. Published by Wiley

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

13/06/2017

Publication date

2018

Notes

This is the peer reviewed version of the following article: YEUNG, W., MORGAN, K. and MCKENNA, F., 2018. Comparison of sleep structure and psychometric profiles in patients with fibromyalgia, osteoarthritis and healthy controls. Journal of Sleep Research, 27(2), pp. 290-298., which has been published in final form at https://doi.org/10.1111/jsr.12588. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

ISSN

0962-1105

eISSN

1365-2869

Language

en