Construction of macrocyclic thiodepsipeptides: synthesis of a nosiheptide 'southern hemisphere' model system

Kimber, Marc; Moody, Christopher J.

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Construction of macrocyclic thiodepsipeptides: synthesis of a nosiheptide 'southern hemisphere' model system

journal contribution

posted on 2014-01-08, 14:59 authored by Marc KimberMarc Kimber, Christopher J. Moody

A 20-membered macrocyclic thiodepsipeptide has been synthesized as a model for the southern hemisphere of nosiheptide, the key steps being assembly of an acyclic precursor by amide coupling of indole and thiazole fragments followed by formation of the thiolactone in the macrocyclization step.

History

School

Science

Department

Chemistry

Citation

KIMBER, M.C. and MOODY, C.J., 2008. Construction of macrocyclic thiodepsipeptides: synthesis of a nosiheptide 'southern hemisphere' model system. Chemical Communications, (5), pp. 591 - 593.

Publisher

Version

VoR (Version of Record)

Publication date

2008

Notes

This article is closed access, it was published in the journal Chemical Communications [© The Royal Society of Chemistry]. The definitive version is available at: http://dx.doi.org/10.1039/b715644h