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10.1007%2Fs40279-018-0909-1.pdf (397.19 kB)

Cross-sectional associations of reallocating time between sedentary and active behaviours on cardiometabolic risk factors in young people: An International Children’s Accelerometry Database (ICAD) analysis

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posted on 2018-05-15, 13:17 authored by Bjorge Hansen, Sigmund Anderssen, Lars Bo Andersen, Maria Hildebrand, Elin Kolle, Jostein Steene-Johannessen, Susi Kriemler, Angie S. Page, Jardena J. Puder, John J. Reilly, Luis B. Sardinha, Esther M.F. van Sluijs, Niels Wedderkopp, Ulf Ekelund, Andrew J. Atkin, Greet Cardon, Rachel Davey, Dale EsligerDale Esliger, Pedro Hallal, Kathleen F. Janz, Niels Moller, Kate Northstone, Russel Pate, Jo Salmon, Lauren SherarLauren Sherar, Anna Timperio
Introduction: Sedentary time and time spent in various intensity-specific physical activity are co-dependent, and increasing time spent in one behaviour requires decreased time in another. Objective: The aim of the present study was to examine the theoretical associations with reallocating time between categories of intensities and cardiometabolic risk factors in a large and heterogeneous sample of children and adolescents. Methods: We analysed pooled data from 13 studies comprising 18,200 children and adolescents aged 4–18 years from the International Children’s Accelerometry Database (ICAD). Waist-mounted accelerometers measured sedentary time, light physical activity (LPA) and moderate-to-vigorous physical activity (MVPA). Cardiometabolic risk factors included waist circumference (WC), systolic blood pressure (SBP), fasting high- and low-density lipoprotein cholesterol (HDL-C and LDL-C), triglycerides, insulin, and glucose. Associations of reallocating time between the various intensity categories with cardiometabolic risk factors were explored using isotemporal substitution modelling. Results: Replacing 10 min of sedentary time with 10 min of MVPA showed favourable associations with WC, SBP, LDL-C, insulin, triglycerides, and glucose; the greatest magnitude was observed for insulin (reduction of 2–4%), WC (reduction of 0.5–1%), and triglycerides (1–2%). In addition, replacing 10 min of sedentary time with an equal amount of LPA showed beneficial associations with WC, although only in adolescents. Conclusions: Replacing sedentary time and/or LPA with MVPA in children and adolescents is favourably associated with most markers of cardiometabolic risk. Efforts aimed at replacing sedentary time with active behaviours, particularly those of at least moderate intensity, appear to be an effective strategy to reduce cardiometabolic risk in young people.


The authors would like to thank all participants and funders of the original studies who contributed data to the ICAD. Pooling of the data was funded through a grant from the National Prevention Research Initiative (grant number G0701877; http://www.mrc.ac.uk/research/initiatives/national-prevention-research-initiative-npri/). The funding partners relevant to this award are the British Heart Foundation, Cancer Research UK, Department of Health, Diabetes UK, Economic and Social Research Council, Medical Research Council, Research and Development Office for the Northern Ireland Health and Social Services, Chief Scientist Office, Scottish Executive Health Department, The Stroke Association, Welsh Assembly Government, and World Cancer Research Fund. This work was additionally supported by the Medical Research Council (MC_UU_12015/3; MC_UU_12015/7), Bristol University, Loughborough University, and Norwegian School of Sport Sciences. The research was additionally supported by the Research Council of Norway (249932/F20). The UK Medical Research Council and the Wellcome Trust (grant reference 102215/2/13/2), as well as the University of Bristol, provide core support for the Avon Longitudinal Study of Parents and Children (ALSPAC).



  • Sport, Exercise and Health Sciences

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Sports Medicine


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HANSEN, B. ... et al, 2018. Cross-sectional associations of reallocating time between sedentary and active behaviours on cardiometabolic risk factors in young people: An International Children’s Accelerometry Database (ICAD) Analysis. Sports Medicine, 48 (10), pp.2401–2412.


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This is an Open Access Article. It is published by Springer International Publishing under the Creative Commons Attribution 4.0 International Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/






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